Mar 30, 2025 · LAMB3 (Laminin Subunit Beta 3) is a Protein Coding gene. Diseases associated with LAMB3 include Epidermolysis Bullosa, Junctional 1B, Severe and Epidermolysis Bullosa, Junctional 1A, Intermediate. Among its related pathways are Integrin Pathway and ERK Signaling.

The LAMB3 gene provides instructions for making one part (subunit) of a protein called laminin 332 (formerly known as laminin 5). Learn about this gene and related health conditions.

Laminin subunit beta-3 is a protein that in humans is encoded by the LAMB3 gene. [5] [6] [7] LAMB3 encodes the beta 3 subunit of laminin. Laminin is composed of three subunits (alpha, beta, and gamma), and refers to a family of basement membrane proteins. For example, LAMB3 serves as the beta chain in laminin-5.

Feb 9, 2025 · Title: A novel splice-site variant of the LAMB3 gene is associated with junctional epidermolysis bullosa. Novel LAMB3 variants in two Asian patients and an overview of LAMB3 variants associated with generalized intermediate junctional epidermolysis bullosa.

Sep 1, 2024 · Laminin subunit beta 3 (LAMB3), a component of laminin 5, functions as an adhesive protein in the extracellular matrix and plays a vital role in regulating cell proliferation, migration, and cell cycle in certain diseases.

Genetic analysis of LAMB3 detected compound heterozygosity for the R635X nonsense mutation (150310.0001) and a novel 2-bp deletion (1587delAG; 150310.0011), resulting in a downstream premature termination codon.

Mar 8, 2019 · Our results showed that LAMB3 could mediate cell cycle arrest and apoptosis in PDAC cells and alter the proliferative, invasive, and metastatic behaviors of PDAC by regulating the PI3K/Akt...

Laminin subunit beta 3 (LAMB3), a component of laminin 5, functions as an adhesive protein in the extracellular matrix and plays a vital role in regulating cell proliferation, migration, and cell cycle in certain diseases.

Mutations in this gene cause epidermolysis bullosa junctional Herlitz type, and generalized atrophic benign epidermolysis bullosa, diseases that are characterized by blistering of the skin. Multiple alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Cox regression and Nomogram analysis show that LAMB3 is an independent risk factor for 15 cancers. LAMB3 is implicated in a variety of tumorigenesis and immune-related signaling pathways, according to GO, KEGG, and GSEA results.