The aims of this study were to assess whether plasma and aortic concentrations of low-density lipoprotein receptor-related protein 1 (LRP1) are associated with AAA, and to investigate the …

Published evidence suggests that LRP1 may play a key role in the development of AAA. A recent genome wide association study has demonstrated a highly significant association between …

Our findings suggest a mechanism contributing to AAA formation via the LRP1 pathway, and exploration of this mechanism could provide future therapeutic approaches to preventing the …

Crucially animal studies have shown that LRP1 depletion leads to progressive destruction of the vascular architecture and aneurysm formation. Conclusions: Published evidence suggests that …

Oct 1, 2015 · MMP9, an LRP1 ligand, is overexpressed in human and mouse AAA biopsies, and is implicated in AAA pathogenesis. 1, 31 The current study suggests a role for LRP1 in …

Nov 13, 2014 · The present study demonstrated that LRP1 protein abundance was equivalent throughout all arterial regions examined. Surprisingly, deletion of LRP1 in SMCs had no effect …

Nov 1, 2013 · There are no published data on the expression of low-density lipoprotein receptor-related protein 1 (LRP1) in human aortic tissues with abdominal aortic aneurysm (AAA), …

The prevalence of carriers of the rs1466535 LRP1 T allele was higher in patients (51.8%) than in control subjects (39.7%, P = .0004), suggesting a risk effect for AAA. rs6674171 …

Nov 11, 2011 · Our findings suggest a mechanism contributing to AAA formation via the LRP1 pathway, and exploration of this mechanism could provide future therapeutic approaches to …

Nov 6, 2021 · An increasing body of evidence demonstrates that genetic factors, including 3p12.3, DAB2IP, LDLr, LRP1, MMP3, TGFβR2 and SORT1 loci, are associated with AAA development.