LRPs in WNT Signalling - PubMed
The WNT/β-catenin signalling pathway is a rich and complex network of cellular proteins that orchestrates diverse short-range cell-to-cell communication in metazoans and is essential for …
Frizzled and LRP5/6 Receptors for Wnt/β-Catenin Signaling
Frizzled and LRP5/6 are Wnt receptors that upon activation lead to stabilization of cytoplasmic β-catenin. In this study, we review the current knowledge of these two families of receptors, …
LRP5 and LRP6 in Wnt Signaling: Similarity and Divergence
LRP5 and LRP6 are highly homologous and widely co-expressed in embryonic and adult tissues, and they share similar function in mediating Wnt signaling. However, they also exhibit distinct …
LRP5 and LRP6 in Wnt Signaling: Similarity and Divergence
May 6, 2021 · In vertebrates, low density lipoprotein receptor-related proteins 5 and 6 (LRP5 and LRP6), the single-pass transmembrane proteins, act as coreceptors of Wnt ligands and are …
Distinct roles of LRP5 and LRP6 in Wnt signaling regulation in the ...
Our studies for the first time demonstrated that most Wnt ligands activate Wnt signaling through LRP6, suggesting a predominant role of LRP6 in mediating Wnt signaling, and that LRP6 may …
Dissecting Molecular Differences between Wnt Coreceptors LRP5 …
Low-density lipoprotein receptor-related proteins 5 and 6 (LRP5 and LRP6) serve as Wnt co-receptors for the canonical β-catenin pathway. While LRP6 is essential for embryogenesis, …
Structural and Functional Studies of LRP6 Ectodomain ... - Cell Press
Nov 15, 2011 · LDL-receptor-related protein 6 (LRP6), alongside Frizzled receptors, transduces Wnt signaling across the plasma membrane. The LRP6 ectodomain comprises four tandem β …
LRPs in WNT Signalling | SpringerLink
Sep 7, 2021 · The WNT/β-catenin signalling pathway is a rich and complex network of cellular proteins that orchestrates diverse short-range cell-to-cell communication in metazoans and is …
Structural Basis of Wnt Signaling Inhibition by Dickkopf Binding to ...
Nov 15, 2011 · We present the crystal structure of the Dkk1 C-terminal domain bound to LRP6 (3-4), and show that the Dkk1 N-terminal domain binds to LRP6 (1-2), demonstrating that a single …
Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling
Dec 1, 2012 · Frizzled and LRP5/6 are Wnt receptors that upon activation lead to stabilization of cytoplasmic β-catenin. In this study, we review the current knowledge of these two families of …