LRP6 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP5. In each protein, about 85% of its 1600- amino-acid length is extracellular. Each has four …

Mar 30, 2025 · Complete information for LRP6 gene (Protein Coding), LDL Receptor Related Protein 6, including: function, proteins, disorders, pathways, orthologs, and expression.

Biochemical and genetic studies have discovered that members of the LDL receptor-related (LRP) family, specifically LRP5 and LRP6 in vertebrates, are coreceptors of the canonical Wnt …

Jul 11, 2017 · Low-density lipoprotein receptor protein 6 (LRP6) is a Wnt co-receptor with essential functions in the Wnt/β-catenin pathway, and mutations in LRP6 gene are linked to …

Nov 15, 2011 · LDL-receptor-related protein 6 (LRP6), alongside Frizzled receptors, transduces Wnt signaling across the plasma membrane. The LRP6 ectodomain comprises four tandem β …

Jan 1, 2013 · These studies identify LRP-6 and signaling pathways downstream of LRP-6 as therapeutic targets to intervene in fibrogenesis of the kidney. In addition, they identify the …

Dec 17, 2012 · How Wnt proteins, or some known inhibitors of LRP5/6 such as DKK1 and SOST, bind to the LRP5/6 extracellular domain (ECD) to regulate Wnt signaling are key questions. …

Low-density lipoprotein receptor-related protein 6 (LRP6) serves as a Wnt coreceptor. Although Wnt/LRP6 signalling is best known for the β-catenin-dependent regulation of target genes in …

LRP6 is a lipid raft receptor protein that consists of LDL receptor (LDLR)–like binding domains and a cytoplasmic YXXL motif, and undergoes coated-pit–mediated internalization after Wnt …

Jan 10, 2022 · LRP6 is a member of the low-density lipoprotein receptor superfamily of cell-surface receptors. It is required for the activation of the Wnt/β-catenin signalling pathway.