Sirt3 mitigates LPS‐induced mitochondrial damage in renal …
Functional studies revealed that Sirt3 overexpression alleviated LPS‐induced mitochondrial damage and apoptosis in TECs by promoting OPA1‐mediated mitochondrial fusion through …
LPS causes pericyte loss and microvascular dysfunction via
Feb 12, 2016 · Sirtuin 3 (SIRT3) mediates histone protein post-translational modification related to aging and ischemic disease. This study investigated the involvement of SIRT3 in LPS-induced …
Sirt3 mitigates LPS-induced mitochondrial damage in renal …
Nov 26, 2022 · Functional studies revealed that Sirt3 overexpression alleviated LPS-induced mitochondrial damage and apoptosis in TECs by promoting OPA1-mediated mitochondrial …
Mitochondrial Sirtuin 3: New emerging biological function and ...
SIRT3 can maintain bone metabolism by enhancing the AMPK-PGC-1β axis 169. SIRT3 can also protect microvasculature from LPS-induced damage. LPS upregulates Ang-2, leading to …
Polydatin protects against lipopolysaccharide-induced endothelial ...
Oct 22, 2019 · Our results suggest that polydatin protects against LPS-induced endothelial barrier disruption dependent on SIRT3 and can be applied as a potential therapy for sepsis.
LPS causes pericyte loss and microvascular dysfunction via disruption ...
Feb 12, 2016 · Sirtuin 3 (SIRT3) mediates histone protein post-translational modification related to aging and ischemic disease. This study investigated the involvement of SIRT3 in LPS-induced …
Brazilin alleviates acute lung injury via inhibition of ferroptosis ...
Dec 25, 2024 · Sirtuin 3 (SIRT3) was identified as a downstream target of brazilin, and overexpression of SIRT3 mirrored the protective effects of brazilin against LPS-induced ALI. …
SIRT3 Alleviates LPS-Induced Acute Kidney Injury through Notch1 …
Silent information regulator 2-related enzyme 3 (SIRT3) plays an important role in kidney diseases, including AKI. The aim of this study was to investigate the effect of SIRT3 on AKI in …
Sirt3 Maintains Microvascular Endothelial Adherens Junction …
Sirt3-mediated VE-cadherin/β-catenin complex maintained microvascular endothelial adherens junction integrity to suppress inflammation. (a) The protein expression and relative quantitative …
SIRT3 diminishes inflammation and mitigates endotoxin-induced …
We found that SIRT3 expression was significantly diminished in lungs of mice subjected to LPS-induced ALI. SIRT3-deficient mice (SIRT3 –/–) develop more severe ALI compared with wild …
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