Nov 1, 2005 · In this study, we describe that LPS is a strong inducer of CD40 expression in macrophages and microglia, which occurs at the transcriptional level and involves the …

CD40 plays important roles in cell-mediated and humoral immune responses. In this study, we explored mechanisms underlying lipopolysaccharide (LPS)-induced CD40 expression in …

Feb 23, 2023 · Here we show that CD40 activation triggers fatty acid oxidation (FAO) and glutamine metabolism to promote ATP citrate lyase-dependent epigenetic reprogramming of …

Nov 1, 2005 · Blocking IFN-beta-induced activation of STAT-1alpha by IFN-beta-neutralizing antibody reduces LPS-induced CD40 gene expression. Furthermore, LPS induces acetylation …

Apr 13, 2018 · We examined responses of blood myeloid (m)DC1s, mDC2s, plasmacytoid (p)DCs, and monocyte-derived DCs (MoDCs) from young (21–40 years) and elderly (60–84 …

Sep 6, 2013 · We examine three-well-studied B-cell-activating protocols: CD40 ligation as a typical T-cell stimulus, TLR4 stimulation by lipopolysaccharide (LPS) as an external innate …

Apr 20, 2008 · LPS can induce increased gene expressions in AMΦ, such as TLR4, CD40, TNF-α, MIP-2, and IL-1β, and activate some signal transduction pathways such as TLR4-mediated …

Apr 13, 2018 · We examined responses of blood myeloid (m)DC1s, mDC2s, plasmacytoid (p)DCs, and monocyte-derived DCs (MoDCs) from young (21–40 years) and elderly (60–84 …

May 17, 2004 · CD40, like BAFF and LPS, can rescue primary B lymphocytes from in vitro spontaneous apoptosis and, like LPS, can also induce B cell proliferation and Ig isotype …

We compared the ability of progesterone to modulate murine bone marrow-derived DC cytokine production (IL-6 and IL-12) and costimulatory molecule expression (CD40, CD80, and CD86) …