Hdac7 promotes lung tumorigenesis by inhibiting Stat3 activation
Mechanistic study revealed that Hdac7 mutation in mouse lung tumors or HDAC7 depletion in human tumor cell lines resulted in significantly enhanced acetylation and tyrosine …
Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific …
Histone deacetylases (HDACs) are protein deacetylases that play a role in repression of gene transcription and are emerging targets in cancer therapy. Here, we characterize the structure …
HDAC7 promotes NSCLC proliferation and metastasis via …
- To investigate the role of HDAC7 on NSCLC malignant progression, we established HDAC7 overexpression and knockdown NSCLC cell lines with lentiviral infection based on the basal HDAC7 levels of NSCLC cell lines (Fig. S1a). Compared with control groups, HDAC7 overexpression remarkably increased cell viability detected by CCK-8 analysis (Fig. 1f). Mor...
- Studies of LO2 HDAC7
HDAC7 is an immunometabolic switch triaging danger signals for …
Jan 24, 2023 · The immune system must be able to respond to a myriad of different threats, each requiring a distinct type of response. Here, we demonstrate that the cytoplasmic lysine …
Evidence that HDAC7 acts as an epigenetic “reader” of …
Jul 21, 2022 · Zhang et al. report evidence for the epigenetic-reader function of histone deacetylase 7 (HDAC7). A model is proposed where transcription by androgen receptor (AR) is activated by binding of the AR K630 acetylation site …
HDAC7 Is a Repressor of Myeloid Genes Whose …
May 16, 2013 · In this article, we examined the molecular mechanism responsible for the gene silencing of lineage undesirable genes in B cell precursors and …
- Author: Bruna Barneda-Zahonero, Lidia Román-González, Olga Collazo, Haleh Rafati, Abul B. M. M. K. Islam, La...
- Publish Year: 2013
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HDAC7: a promising target in cancer - Frontiers
Feb 28, 2024 · HDAC7 facilitates β-catenin redistribution to the nucleus by deacetylating β-catenin and inhibiting its phosphorylation, which results in that the nuclear accumulation of β-catenin binds to TCF/LEF to activate related gene …
Evidence that HDAC7 acts as an epigenetic "reader" of AR
Jul 21, 2022 · Documenting the biological consequences of this possible reader function, mutation of a critical acetylation site regulated androgen receptor (AR) transcriptional activation function …
Human HDAC7 harbors a class IIa histone deacetylase-specific …
Apr 25, 2008 · Here, we characterize the structure and enzymatic activity of the catalytic domain of human HDAC7 (cdHDAC7). Although HDAC7 normally exists as part of a multiprotein …
HDAC7 Gene - GeneCards | HDAC7 Protein | HDAC7 …
Mar 30, 2025 · HDAC7 (Histone Deacetylase 7) is a Protein Coding gene. Diseases associated with HDAC7 include Hematologic Cancer. Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants …
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