Ionization and structural properties of mRNA lipid nanoparticles ...
Aug 11, 2021 · Lipid Nanoparticles (LNPs) are used to deliver siRNA and COVID-19 mRNA vaccines. The main factor known to determine their delivery efficiency is the pKa of the LNP …
The Importance of Apparent pKa in the Development of Nanoparticles ...
Jun 1, 2021 · We highlight the significant impact of the apparent pKa of nanoparticles on their efficacy and toxicity, and the importance of optimizing pKa in the development of lead …
pKa of Lipids in Drug Delivery - BroadPharm
Mar 13, 2024 · The pKa value of ionizable lipids, used in LNPs, significantly influences the success of RNA delivery into cells. The apparent pKa is the pH where the quantities of ionized …
Artificial intelligence-driven rational design of ionizable ... - Nature
Dec 30, 2024 · This study leverages artificial intelligence (AI) and virtual screening to facilitate the rational design of ionizable lipids by predicting two key properties of LNPs, apparent pKa and …
Key Design Features of Lipid Nanoparticles and Electrostatic …
In this review, we discuss the key design aspects that confer efficacy to a LNP delivery system, i.e., potency, biodegradability, and immunogenicity. We also cover the underlying …
Calculating Apparent pKa Values of Ionizable Lipids in Lipid ...
Dec 10, 2024 · We have developed a structure-based, computational methodology for the prediction of the apparent p Ka value of ionizable lipids within LNPs and have tested it using …
research. One of the critical properties for selecting suitable ionizable lipids is the apparent pKa value of the lipid as formulated in an LNP. We have developed a structure-based, …
Calculating Apparent p Ka Values of Ionizable Lipids in Lipid ...
Dec 10, 2024 · We have developed a structure-based, computational methodology for the prediction of the apparent p Ka value of ionizable lipids within LNPs and have tested it using …
The Importance of Apparent pKa in the Development of …
We highlight the significant impact of the apparent pKa of nanoparticles on the efficacy and toxicity of the nanoparticles and the importance of optimizing pKa in the development of lead …
Prediction of the Apparent pKa Value of Lipid Nanoparticles by …
Feb 28, 2025 · One of the most important parameters for the development of novel ionizable lipids (ILs) for use in lipid nanoparticle (LNP) drug carriers is their p Ka value. Ideally, the LNP …