Lipid nanoparticles for mRNA delivery - Nature Reviews Materials
Aug 10, 2021 · In this Review, we discuss the design of lipid nanoparticles for mRNA delivery and examine physiological barriers and possible administration routes for lipid nanoparticle–mRNA …
Size and Charge Characterization of Lipid Nanoparticles for mRNA ...
Mar 22, 2022 · Lipid nanoparticles (LNPs) represent a nonviral leading vector for mRNA delivery. Physicochemical parameters of LNPs, including their size and their charge, directly impact …
A Unified Strategy to Improve Lipid Nanoparticle Mediated mRNA …
Sep 1, 2023 · Here, we report a generalizable strategy that can be utilized to improve the delivery of mRNA drugs using lipid nanoparticles (LNPs), the clinically approved chemistry platforms …
Reformulating lipid nanoparticles for organ-targeted mRNA
Jul 5, 2024 · Here, we reformulate lipid nanoparticles (LNPs) through adjustments in lipid material structures and compositions to systematically achieve the pulmonary and hepatic …
Polysarcosine-Functionalized Lipid Nanoparticles for Therapeutic …
Sep 25, 2020 · Here, lipid nanoparticles (LNPs) for therapeutic application of messenger RNA were assembled using pSarcosinylated lipids as a tool for particle engineering.
Encapsulation state of messenger RNA inside lipid nanoparticles
Jul 20, 2021 · Lipid nanoparticles (LNPs) have emerged as the most promising nonviral delivery vehicle for exogenous mRNA (5, 6). The LNP is a complex nanostructured entity that serves to …
Enhancing natural killer cells proliferation and cytotoxicity using ...
Sep 10, 2024 · Herein, we described the development of Lx (iCD-Lx) and LNP (iD-LNP) that are highly efficient for mRNA delivery in NK cells. Both formulations share the same ionizable lipid …
Rational Design of Anti-Inflammatory Lipid Nanoparticles for …
We demonstrated that Dex-incorporated LNPs effectively abrogated the induction of tumor necrosis factor alpha (TNF-ɑ) in vitro and significantly reduced its expression in vivo. Reducing …
Best practices for characterizing RNA lipid nanoparticles
Sep 7, 2023 · To improve early-stage research in the field of RNA lipid nanoparticles, there are several best practices to be considered for the collection, interpretation and reporting of …
Combinatorial design of ionizable lipid nanoparticles for muscle ... - PNAS
To facilitate tissue-specific mRNA delivery with improved precision, our study presents a platform to quickly create chemically diverse lipids for building LNPs.