Jul 2, 2021 · Vasculature is LMO2- in adult and fetal heart, brain of older adults, hepatic sinusoids, and hepatocellular carcinoma (Am J Clin Pathol 2009;131:264)

Feb 26, 2020 · Immunoperoxidase studies confirm that the tumor cells are positive for CD20, CD10, BCL6, LMO2 and BCL2 (dim) and negative for CD3 and CD5. The proliferation rate of lymphoma cells, measured by Ki67 (MIB1), is ~10%. These morphologic and immunophenotypic findings support the above interpretation.

LIM domain only 2 (LMO2) is a transcription factor that regulates vascular and hematopoietic systems and is involved in hematolymphoid neoplasia. LMO2 is preferentially expressed by germinal center B cells and may also be expressed in erythroid and myeloid precursors and in megakaryocytes.

IHC staining is essential for the diagnosis of various lymphomas. It is crucial that the pathologists select appropriate markers according to the clinical situation of the patient, the H&E staining results, and accurately interpret the IHC results for an optimal lymphoma diagnosis.

In normal tonsil, LMO2 immunohistochemistry staining shows strong nuclear positivity in (A) germinal center B cells (IHC, x40) and (B) endothelial cells (IHC, x100), while LMO2 is negative in (B) surrounding normal T-cells (IHC, x100) C.

OriGene Anti-LMO2 Monoclonal (OTI1C8), TrueMAB™, Catalog # TA506139S. Tested in Western Blot (WB) and Immunohistochemistry (Paraffin) (IHC (P)) applications. This antibody reacts with Human samples. Supplied as 30 µL purified antibody (1 mg/mL).

Meet the Marker: LMO2 Most people familiar with Immunohistochemistry (IHC) are aware of its diagnostic properties. However, the prognostic capability of IHC is equally as important. LIM Domain Only 2 (LMO2) may be a marker capable of both. LMO2 is a protein involved in the scaffolding of transcription factors for

LMO2 antibody has shown usefulness as part of an IHC panel of germinal center-associated markers in eliminating cases of Diffuse Follicle Center Lymphoma. This is accomplished by taking into consideration the histologic and immunoarchitectural spectrum of Nodal Marginal Zone Lymphoma (NMZL) and the immunohistochemical analysis for CD43, CD23 ...

LIM domain only 2 (LMO2) is a transcription factor that regulates vascular and hematopoietic systems and is involved in hematolymphoid neoplasia. LMO2 is preferentially expressed by germinal center B cells and may also be expressed in erythroid and myeloid precursors and in megakaryocytes.

Oct 22, 2024 · With this, we have assessed whether the combination of CD10, LMO2, and MYC expression detected by IHC offers superior results as a screening tool to identify MYCr in comparison to the individual detection of LMO2 or MYC based on CD10 expression.