In this study, we demonstrated that LL-37 modulated PGN-induced inflammatory monocytes and induced their polarization towards the CD14 high CD16 + subset, eventually causing them to differentiate into iDCs. These iDCs not only displayed enhanced expression of CD1a, CD86, and MHC class II molecules but also showed an improved ability to elicit T ...

Qian L., Chen W., Sun W., et al. Antimicrobial peptide LL-37 along with peptidoglycan drive monocyte polarization toward CD14(high)CD16(+) subset and may play a crucial role in the pathogenesis of psoriasis guttata.

Jul 29, 2014 · We showed that CD14 + monocytes are the primary cells that produce pro-inflammatory tumour necrosis factor- α (TNF- α) following stimulation of PBMC with IL-32. We demonstrated that LL-37 and IG-19 significantly suppress IL-32-induced production of pro-inflammatory cytokines, e.g. TNF- α and IL-1 β, without altering chemokine production.

Jan 15, 2004 · LL-37-derived DC displayed significantly up-regulated endocytic capacity, modified phagocytic receptor expression and function, up-regulated costimulatory molecule expression, enhanced secretion of Th-1 inducing cytokines, and promoted Th1 responses in vitro.

Oct 1, 2002 · In this report, we demonstrate that LL-37 is a potent antisepsis agent with the ability to inhibit macrophage stimulation by bacterial components such as LPS, lipoteichoic acid, and noncapped lipoarabinomannan. We also demonstrate …

In the present study, we investigated the effect of LL-37 and LTF on blood-derived CD14 + monocytes. Both HDPs triggered a significant release of TNFα, nucleosomes, and monocyte ETs.

LL-37: Antimicrobial peptide. TLR2 and TLR4 inhibition by LL-37. LL-37, also known as hCAP18, is a synthetic peptide derived from the C-terminal region of the human cationic antimicrobial protein (hCAP). LL-37 exhibits a variety of immunomodulatory functions [1, 2].

Aug 1, 2010 · In this study, we investigated the effects of LL-37 on the differentiation of human monocytes into anti-inflammatory macrophages (MΦ-2; driven by M-CSF) versus proinflammatory macrophages (MΦ-1; driven by GM-CSF) as well as on fully differentiated MΦ-1 and MΦ-2.

Jun 15, 2015 · The human cathelicidin LL-37 peptide is overexpressed in psoriasis and has been demonstrated to be a multifunctional modulator of innate immune response elements, including monocytes. Monocytes, categorized into three populations based on the cell surface expression of CD14 and CD16, are activated i …

Dec 31, 2021 · In the present study, we investigated the effect of LL-37 and LTF on blood-derived CD14+ monocytes. Both HDPs triggered a significant release of TNFα, nucleosomes, and monocyte ETs.