Apr 8, 2020 · This article reports the first cellular basis of depressive disorders mediated by the LHb: increased excitatory synaptic transmission in VTA-projecting LHb neurons.

Groos and Helmchen focus on recent insights into LHb connectivity and its functional relevance for different types of aversive and appetitive value-guided behavior, scrutinizing the afferent and efferent connections of the LHb and discussing their functional implications for …

The LHb gets major inputs from the habenula-projecting globus pallidus and the mPFC, sending its efferents to the dopaminergic VTA and SNc, serotonergic dorsal raphe nuclei, and the GABAergic rostromedial tegmental nucleus.

The LHb sends excitatory projections to VTA and RMTg neurons 6–8, which can inhibit dopamine neuron output 9,10. While correlative evidence suggests that LHb neurons convey anti-reward and aversive information, the behavioral consequences of …

Dec 1, 2021 · Rossi et al. systematically compare lateral hypothalamic glutamatergic neurons projecting to LHb and VTA using viral tracing, single-cell sequencing, electrophysiology, and in vivo calcium imaging. The two populations are anatomically, transcriptionally, and …

Jul 13, 2017 · Both the LHb→RMTg→VTA and LHb→medial VTA→cortex connections have been reported to encode aversive signals (Lammel et al., 2012), consistent with our results showing that the activation of glutamatergic PV VP→LHb fibers induces aversion (Figures S6A–S6H).

Nov 20, 2013 · Lateral habenula (LHb) neurons convey aversive and negative reward conditions through potent indirect inhibition of ventral tegmental area (VTA) dopaminergic neurons.

Lateral habenula (LHb) neurons convey aversive and negative reward conditions through potent indirect inhibition of ventral tegmental area (VTA) dopaminergic neurons.

The aversion behaviors induced by activating LHb glutamatergic neurons may be due to its inhibition on reward-activated neurons in VTA. This study suggests that interplay between the LHb and VTA neurons may play a key role in regulating reward and aversion behaviors.

In this paper, we built a computational model for the pathway between the LHb and the ventral tegmental area (VTA) to simulate the different neurophysiological processes with the LHb regulation in healthy and MDD individuals.