Nov 4, 2021 · The GE is anatomically subdivided into the medial ganglionic eminence (MGE), the lateral ganglionic eminence (LGE) and the caudal ganglionic eminence (CGE), in which the MGE and LGE develop into...

Jan 15, 2025 · The current understanding of cortical interneuron generation is that the medial, caudal, and lateral ganglionic eminences (MGE, CGE, and LGE), respectively, give rise to interneurons that...

The four main clusters correspond to progenitor cells and postmitotic cells from the MGE, LGE, and CGE (Fig. 1B). In addition, we identified smaller cell clusters containing oligodendrocyte progenitor cells (OPCs), microglia, endothelial cells, thalamic neurons, and pallial cells (Fig. 1B).

The CGE is distinct from the LGE and MGE in gene expression patterns and progeny produced. Unlike the cells from the MGE, the cells from the CGE were rarely parvalbumin-containing neurons.

Distinct ventral forebrain subpopulations are generated from topographically defined zones; lateral-, medial- and caudal ganglionic eminences (LGE, MGE and CGE), yet key specification factors often span across developing zones contributing to difficulty in defining unique LGE, MGE or CGE profiles.

Mar 10, 2022 · GEs can be divided into three subregions, including lateral, medial and caudal ganglionic eminences (LGE, MGE and CGE). 14, 15, 16, 17 Each subregion expresses specific genes and generates...

Interneurons are primarily generated in the medial, caudal, and lateral ganglionic eminences (MGE, CGE, and LGE) of the ventral embryonic forebrain; these subregions give rise to distinct interneuron subpopulations.

Apr 1, 2018 · The embryonic subpallium of mammals is subdivided into five major proliferative regions: three ganglionic eminences (GEs) initially defined by their location, medial (MGE), lateral (LGE) and caudal (CGE), the preoptic area (POA) and the septum anlage.

Feb 3, 2010 · By combining an inducible genetic fate mapping strategy with electrophysiological analysis, we have systematically characterized the populations of cortical GABAergic interneurons that originate from the caudal ganglionic eminence (CGE).

Recent progress on the origin of interneurons suggests that these different classes of cells originate from three main sources in the developing subpallium: the medial ganglionic eminence (MGE), the caudal ganglionic eminence (CGE) and the preoptic area (POA), and reach the cortex following different migratory routes (Figure 2).