A plaque-forming unit (PFU) is a measure used in virology to describe the number of virus particles capable of forming plaques per unit volume. [1] It is a proxy measurement rather than a measurement of the absolute quantity of particles: viral particles that are defective or which fail to infect their target cell will not produce a plaque and ...

Aug 10, 2022 · When the hamsters were immunized intramuscularly at a dose of 5 µg/animal, the VSI ranged from 0.2 ± 0.3 to 0.4 ± 0.4 lg PFU·mL −1. In accordance with the Guidelines for Preclinical Studies , the vaccine is effective if the VSI is from 1.2 to 1.8 lg with p < 0.05, at 1.8 lg or more with p < 0.01.

Feb 18, 2023 · Eligible healthy participants aged 1-49 years, with no history of varicella vaccination and had no history of varicella or herpes zoster were sequentially enrolled and allocated to subcutaneously receive one of the three doses (3.3, 3.9, and 4.2 lg PFU) of v7D, vOka or placebo in a dose-escalation and age de-escalation manner.

Dec 4, 2022 · Three doses of the v7D vaccine were prepared and administrated, including 3.3 lg PFU/dose (low dose), 3.9 lg PFU/dose (medium dose), and 4.2 lg PFU/dose (high dose). The placebo formulation was identical to that of the v7D vaccine, except for the absence of the live-attenuated virus.

PFU/mL(Plaque Forming Unit per mL)：单位体积的病毒形成的空斑数，代表有活性的病毒粒子的浓度单位，常用于 腺病毒载体 的滴度标定，属于功能单位。 TU/mL(Transduction Units per mL)：单位体积中成功转导细胞的病毒数量，常用于 慢病毒载体 的滴度测定，属于功能单位。

Dec 10, 2020 · The infectivity titres of harvested virus were between 7.5 and 8.0 Lg PFU/ml. The spike proteins are clearly visible from EM images on the surface of the envelope, suggesting that the native conformation of homotrimers of the spikes remained intact.

Apr 22, 2022 · Aim: To evaluate the immunogenicity and safety of a booster dose of live attenuated varicella vaccine (VarV) manufactured by Sinovac (Dalian) Vaccine Technology Co. Ltd., and the immune persistence of a primary dose in 2- to 6-year-old children. Methods: A phase IV, open-label study was conducted in China.

Mar 24, 2017 · The mutant rJEV (E-177/E-264/E-279/E-315) containing all four point mutations exhibited the lowest immunogenicity with a seroconversion rate of 0 at an inoculation dose of 103 PFU (plaque-forming...

Eligible healthy participants aged 1–49 years, with no history of varicella vaccination and had no history of varicella or herpes zoster were sequentially enrolled and allocated to subcutaneously receive one of the three doses (3.3, 3.9, and 4.2 lg PFU) of v7D, vOka or placebo in a dose-escalation and age de-escalation manner.

百克水痘疫苗执行标准明确规定放行标准病毒滴度应不低于4.0lg PFU/剂，有效期内病毒滴度不低于3.3 lg PFU/剂。 36个月有效期 稳定性高. 水痘—带状疱疹病毒对热极其敏感，稳定性差在有效期内会影响疫苗效力。 百克水痘疫苗是全球首个获得批准的36个月有效期的水痘疫苗，在2~8℃环境下放置40个月，病毒滴度仍然符合国家规定的出厂标准要求。 不含明胶 安全性强. 国外早期研究证明，大多数重度不良反应与明胶有关，去除明胶后，不良反应，特别是重度不良反应大大降低 …