Lymphocyte function-associated antigen 1 (LFA-1) is an integrin found on lymphocytes and other leukocytes. [1] LFA-1 plays a key role in emigration, which is the process by which leukocytes …

LFA-1 (Lymphocyte function-associated antigen-1) is a heterodimeric integrin (CD11a/CD18) present on the surface of all leukocytes; it is essential for leukocyte recruitment to the site of …

Mar 25, 2022 · Absent or dysfunctional expression of LFA-1, caused by mutations in the ITGB2 (integrin subunit beta 2) gene, results in a rare immunodeficiency syndrome known as …

The lymphocyte function-associated antigen-1 (LFA-1) (also known as CD11a/CD18 and αLβ2), is just one of many integrins in the human body, but its significance is derived from its exclusive …

Jul 21, 2021 · Here, we briefly summarize current knowledge of LFA-1 biology, discuss novel cytoskeletal regulators of LFA-1 functions, and review new aspects of LFA-1 mechanobiology …

This review will discuss our current understanding of the role of LFA-1 during T cell activation, effector functions, and memory formation. LFA-1 Structure LFA-1 is composed of α- and β- …

Aug 1, 2021 · LFA-1 is a mechanosensitive adhesion receptor that couples mechanical forces to fine-tune T cell migration, differentiation, and effector functions.

Nov 1, 2003 · These studies provide compelling evidence that LFA-1 can indeed transmit signals that promote T cell activation and differentiation.

Lymphocyte function-associated antigen 1 (LFA-1, also called CD11a/CD18 and αL β 2) is an integrin heterodimer expressed on T cells that interacts with ICAM-1 on endothelial cells and …

Dec 29, 2024 · LFA-1 is the acronym for "Lymphocyte function-associated antigen 1", an integrin that is expressed by lymphocytes and other leukocytes. LFA-1 thus belongs to the integrin …