In toxicology, the median lethal dose, LD 50 (abbreviation for "lethal dose, 50%"), LC 50 (lethal concentration, 50%) or LCt 50 is a toxic unit that measures the lethal dose of a given substance. [1] The value of LD 50 for a substance is the dose required to kill half the members of a tested population after a specified test duration.

May 10, 2024 · LD 50 is the amount of a material, given all at once, which causes the death of 50% (one half) of a group of test animals. The LD 50 is one way to measure the short-term poisoning potential (acute toxicity) of a material.

The median lethal dose, LD 50 (abbreviation for "lethal dose, 50%"), LC 50 (lethal concentration, 50%) or LCt 50 (lethal concentration and time) of a toxin, radiation, or pathogen is the dose required to kill half the members of a tested population after a specified test duration.

Feb 11, 2018 · The median lethal dose, or LD50, is a term used in toxicology as a measurement of a lethal dose of a substance (e.g., pathogen, medication, toxic substance, etc.). Specifically, the LD50 represents the dose at which a substance is lethal for 50% of tested subjects.

Jun 17, 2016 · LD50 and LC50. LD50 (Lethal Dose 50%) is a statistically derived dose at which 50% of the animals will be expected to die. For inhalation toxicity, air concentrations are used for exposure values. Thus, the LC50 (Lethal Concentration 50%) is used.

Median lethal dose (LD50) is commonly expressed in mg/kg, by oral intake or skin exposure. Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved. In pharmacology, a dose that proves lethal to 50% of a given population. The dose of a …

Aug 11, 2022 · The LD 50 is a standardized measure for expressing and comparing the toxicity of chemicals. The LD 50 is the dose that kills half (50%) of the animals tested (LD = "lethal dose"). The animals are usually rats or mice, although rabbits, guinea pigs, hamsters, and so on are sometimes used.

Sep 22, 2024 · The concept of LD50, or lethal dose 50%, is pivotal in toxicology and pharmacology. It refers to the amount of a substance required to kill 50% of a test population, providing critical insights into the toxicity of compounds. Understanding LD50 values helps professionals evaluate risk, safety margins, and potential therapeutic uses.

Jan 1, 2024 · The amount of a chemical agent that is expected to kill 50% of the test organisms when given directly under the test’s stated conditions. For many years, the gold standard for determining acute toxicity between toxicants and species was …

Jun 20, 2014 · LD50 is a measurement used in toxicology studies to determine the potential impact of toxic substances on different types of organisms. It provides an objective measure to compare and rank the toxicity of substances.