Autophagy is required for toll-like receptor-mediated interleukin-8 ...
Cells treated with the TLR ligands produced considerable amounts of pro-inflammatory cytokines (IL-8, CINC-2β, MIP-2). Furthermore, the basal levels of LC3-II were markedly higher in IECs …
LC3-associated phagocytosis protects against inflammation and …
Apr 15, 2020 · Now, Wan et al. showed that a noncanonical form of autophagy called LC3-associated phagocytosis (LAP) is a protective mechanism activated in monocytes during liver …
Interleukin-8 released by cancer-associated fibroblasts attenuates …
Mar 1, 2021 · Interleukin (IL)-8 was found to be the most highly upregulated cytokine among the cytokines/chemokines found in the OVCAF-CM. The role of IL-8 in ovarian cancer cell …
The Role of Interleukin-8 and its Receptors in Inflammatory Lung ...
The CXC chemokine interleukin (IL)-8, is a potent neutrophil recruiting and activating factor and the detection of IL-8 in clinical samples from patients with these diseases has led clinicians to …
Beyond autophagy: LC3-associated phagocytosis and endocytosis
Oct 26, 2022 · LC3 lipidation aids in autophagosome trafficking and directs autophagosome/lysosome fusion events as well as other functions including cargo selection in …
Interleukin 8 - Wikipedia
Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells [3] and …
Phospholipase C-β3 Is a Key Modulator of IL-8 Expression in Cystic ...
Apr 15, 2011 · The chemokine IL-8 is the most abundant soluble mediator recruiting neutrophils in the bronchi of CF patients, being found in the airway secretions both in advanced and in early …
IL-8 and PI3K pathway influence the susceptibility of TRAIL
Sep 13, 2024 · Data from RT-qPCR and Western blotting revealed the molecular regulations of IL-8 on TRAIL decoy receptor genes (OPG) and autophagy-related genes (BECN1 and LC3B) …
Interleukin-8 Regulates the Autophagy and Apoptosis in Gastric …
Aug 11, 2022 · In contrast to the IL-8 group, the invasion quantity of gastric cancer SGC7901 cells in the IL-8 + LY294002 group was considerably decreased. Conclusion: IL-8 promotes …
Gang of 3: How the Krebs cycle-linked metabolites ... - Cell Press
Mar 31, 2025 · The Krebs cycle intermediates itaconate, succinate, and fumarate act as immunometabolites to regulate macrophage immune responses. This review highlights how …