L cells secrete glucagon-like peptide-1, an incretin, peptide YY 3-36, oxyntomodulin and glucagon-like peptide-2. L cells are primarily found in the ileum and large intestine (colon), but some are also found in the duodenum and jejunum .

With a view to home in on what an L-cell is, we here present an overview of available data on L-cell development, L-cell peptide expression profiles, peptide production and secretory patterns of L-cells from different parts of the gut.

Nov 25, 2022 · L cells are neuroendocrine cells producing glucagon-like peptide 1 (GLP1), glucagon-like peptide 2 (GLP2), peptide YY (PYY), glicentin (Fig. 1), and oxyntomodulin (Böttcher et al. 1984; Fiocca et al. 1987). All these peptides but PYY derive from an alternative posttranscriptional splicing of the proglucagon, the same precursor synthesized by ...

L-cells, which have traditionally been described as having a distinct cone-shaped morphology, secrete the products of cleavage by prohormone convertase 1; GLP-1, glucagon-like peptide 2 (GLP-2), glicentin, and oxyntomodulin (34–36).

Enteroendocrine L-cells have mainly been studied for their function as regulators of postprandial response to nutrients. One prominent feature of L-cells is the expression of the proglucagon gene (Gcg) which is also expressed in pancreatic α-cells.

Dec 1, 2006 · Early studies on L-cell secretagogues used antibodies that targeted a mid-sequence epitope of glucagon, resulting in detection of glicentin/oxyntomodulin (i.e., enteroglucagon or gut glucagon-like immunoreactivity) as well as of glucagon.

Feb 26, 2019 · Enteroendocrine cells are specialized cells found within the gastrointestinal tract, stomach and pancreas. They produce and release hormones in response to a number of stimuli.

Jan 18, 2024 · Here, we find that sympathetic nerves elevate postprandial blood glucose but restrict brain glucose utilization by repressing the release of glucagon-like peptide-1 (GLP-1) from enteroendocrine L cells. Sympathetic nerves are in close apposition with the L cells.

Feb 20, 2025 · L cells are a type of enteroendocrine cell primarily found in the ileum and large intestine (colon), with some also present in the duodenum and jejunum. Their primary function is the secretion of several important hormones.

Dec 6, 2008 · By generating transgenic mice with L cell-specific expression of a fluorescent protein, we studied the characteristics of primary L cells by electrophysiology, fluorescence calcium imaging, and expression analysis and show that single L cells are electrically excitable and glucose responsive.