KRAS (Kirsten rat sarcoma virus) is a gene that provides instructions for making a protein called K-Ras, a part of the RAS/MAPK pathway. The protein relays signals from outside the cell to the cell's nucleus. These signals instruct the cell to grow and divide (proliferate) or to mature and take on specialized functions (differentiate).

Apr 4, 2024 · The most frequently mutated of these oncogenic driver genes, called KRAS, is associated with some of the most fatal cancer types: lung, pancreatic and colorectal cancers.

Nov 15, 2021 · As the most frequently mutated oncogene, Kirsten rat sarcoma viral oncogene homologue (KRAS) has attracted substantial attention. The understanding of KRAS is constantly being updated by numerous...

In this minireview, my aim is to provide the reader an overview of the publicly available KRAS structural data, insights to conformational dynamics revealed by experiments and what we have learned from MD simulations.

Kristen rat sarcoma (KRAS) gene is one of the most common mutated oncogenes in solid tumors. Yet, KRAS inhibitors did not follow suit with the development of targeted therapy, for the structure of KRAS has been considered as being implausible to target for decades.

The KRAS gene provides instructions for making a protein called K-Ras that is part of a signaling pathway known as the RAS/MAPK pathway. The protein relays signals from outside the cell to the cell's nucleus.

Apr 18, 2024 · Herein, we outline RAS pathobiology with a focus on KRAS, illustrate therapeutic approaches across a variety of malignancies, including emphasis on the ‘on’ and ‘off’ switch allele-specific and...

Jan 15, 2025 · Recent studies provide new insights into signaling by mutant KRAS, inhibitors of which have provided modest benefits for patients.

KRAS Kickers is a lung cancer research advocate community. KRAS is the most common biomarker associated with lung, colorectal, plus other cancers. Find resources to help with treatment.

Jan 22, 2025 · Dr. Erin Schenk explains what KRAS mutation is in lung cancer. KRAS is an important biomarker that can impact lung what treatment options. Talk to your doctor about comprehensive biomarker testing.