KIR Receptors as Key Regulators of NK Cells Activity in Health and ...
To a high extent cytotoxic activity of NK cells is regulated inter alia by signals from killer immunoglobulin-like receptors (KIR). The major histocompatibility complex (MHC) class I …
Can we make a better match or mismatch with KIR genotyping?
Dec 2, 2016 · Accumulating data indicate that epistatic interactions between KIR and HLA influence outcomes in several clinical conditions. Herein, we discuss the genetic and functional …
Frontiers | Killer Ig-Like Receptors (KIRs): Their Role in NK Cell ...
May 28, 2019 · The discovery of HLA class I specific inhibitory receptors, primarily of killer Ig-like receptors (KIRs), and of activating receptors has been fundamental to unravel NK cell function …
Education of human natural killer cells by activating killer cell ...
Feb 11, 2010 · Our results suggest that the education of human NK cells via activating KIRs is dependent on the presence of their ligands and represents a mechanism that complements …
Killer Cell Immunoglobulin Like Receptor - ScienceDirect
KIRs are type I transmembrane glycoproteins and consist of either two or three immunoglobulin-like domains (designated KIR2D and KIR3D, respectively) in their extracellular region, a …
Inhibitory killer cell immunoglobulin-like receptors strengthen …
Killer cell immunoglobulin-like receptors (KIRs) are expressed predominantly on natural killer cells, where they play a key role in the regulation of innate immune responses. Recent studies …
The peptide selectivity model: Interpreting NK cell KIR-HLA-I …
Nov 21, 2024 · Recent data have exposed differences between killer-cell immunoglobulin-like receptors (KIRs) in their selective binding to human leukocyte antigen (HLA) class I (HLA-I) …
TLR/NCR/KIR: Which One to Use and When? - PMC
Mar 19, 2014 · Indeed, certain KIRs can function as sensor for microbial products and as chaperons for TLR9 ligands. Remarkably, an inhibitory KIR, such as KIR3DL2, may …
Regulation of KIR expression in human T cells: a safety ... - Cell Press
Apr 1, 1998 · KIRs allow natural killer cells to identify and lyse self cells that do not express sufficient amounts of MHC class I molecules. Here, Maria Cristina Mingari and colleagues …
Kir Recipe – Advanced Mixology
Feb 28, 2022 · Kirs are the absolute drink if there is any leftover at all, and they don't take too long or require many ingredients! Plus, you can make this simple cocktail with anything from red or …
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