It is an integral membrane protein. The protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated …

Kir6.2, a pore-forming subunit of the ATP-sensitive potassium (KATP) channels, regulates the functions of metabolically active tissues and acts as an ideal therapeutic target for multiple …

Here we show that the Kir6.2 pore-forming subunit is significantly overexpressed in the astrocytes of human BC specimens, and we speculate about Kir6.2's potential role in the pathophysiology …

Kir6.2 is a subtype of inwardly rectifying potassium channels that contribute to regulating the resting membrane potential and controlling excitability in various cells. It forms part of KATP …

Mar 20, 2024 · ATP-sensitive potassium (K ATP) channels, composed of four pore-lining Kir6.2 subunits and four regulatory sulfonylurea receptor 1 (SUR1) subunits, control insulin secretion …

Aug 30, 2023 · In this work, MSA was performed on the Kir6.1, Kir6.2 and the new Kir6 sequence that we have named Kir6.3 from the organisms: L. chalumnae, E. calabaricus, X. tropicalis and …

Gain-of-function mutations in Kir6.2 cause permanent neonatal diabetes mellitus (PNDM) by reducing the ATP sensitivity of the K (ATP) channel and increasing the K (ATP) current, which …

Here, we determine the roles of KATP in the PNS using Kir6.2 KATP-deficient ( -deficient) mice. We demonstrate that neurite outgrowth of dorsal root ganglion (DRG) neurons was reduced by …

We reveal, for the first time, dynamical behavior of the Kir6.2/SUR1 system, confirming a physiological role of the Kir6.2 disordered tail, and we indicate structural determinants of KATP …

Oct 15, 2021 · Kir6.2, a pore-forming subunit of the ATP-sensitive potassium (KATP) channels, regulates the functions of metabolically active tissues and acts as an ideal therapeutic target …