The founding member of this superfamily, kinesin-1, was isolated as a heterotetrameric fast axonal organelle transport motor consisting of four parts: two identical motor subunits (called Kinesin Heavy Chain (KHC) molecules) and two other molecules each known as a …

Kinesin-1 is a processive motor protein that can move continuously for several micrometers along microtubules, demonstrating a property known as "processivity." You might find these chapters and articles relevant to this topic.

To realize the fast and processive movement on the microtubule lattice, kinesin-1 efficiently transforms the chemical energy of nucleotide binding and hydrolysis to the energy of mechanical movement. The chemical and mechanical cycle of kinesin-1 …

Kinesin-1, the first-discovered kinesin, has been studied extensively. The development of single-molecule assays and the early finding that single kinesin-1 molecules move processively along microtubules (Howard et al., 1989) made it possible to measure the …

Mar 5, 2021 · Kinesin-1 is a processive motor protein that uses ATP-derived energy to transport a variety of intracellular cargoes toward the cell periphery.

Aug 12, 2011 · Kinesin-1 (previously named conventional kinesin and hereafter called kinesin) is a molecular motor that uses energy from adenosine triphosphate (ATP) hydrolysis to move …

Regulation of Kinesin activity and Kinesin-Cargo interactions determine the direction, timing and flux of various intracellular transports. This review examines how phosphorylation of Kinesin subunits and adaptors influence the traffic driven by Kinesin-1, -2, and -3 family motors.

Jul 1, 2008 · The motor protein kinesin-1 uses energy from ATP hydrolysis to move intracellular cargo to the microtubule plus end. Kinesin-1 is either regulated or activated for cargo movement in response to various cues, ensuring its proper localization and facilitating cargo transport to the right destination.

Mar 9, 2023 · We recorded one-dimensional (1D) traces of individual kinesin dimers labeled with a single fluorophore (degree of labeling of 1, DOL1) on the stalk walking along the microtubule axis (on-axis displacement) with a temporal resolution of ~1 ms and a …

Sep 16, 2022 · The ubiquitous and prototypic kinesin family member, kinesin-1, exists in a predominantly heterotetrameric form, comprising two motor-bearing heavy chains (KHCs) and …