A protein kinase inhibitor (PKI) is a type of enzyme inhibitor that blocks the action of one or more protein kinases. [1] Protein kinases are enzymes that phosphorylate (add a phosphate, or PO …

There are several protein kinase inhibitors that have been approved by FDA in the last few decades. This article provides a review of the clinical benefits and side effect profiles of FDA …

May 12, 2023 · Tyrosine kinase inhibitors (TKIs) are targeted therapies that treat many kinds of cancer. They block certain substances in cancerous cells that manage how fast the cells grow …

Oct 8, 2021 · The central role of dysregulated kinase activity in the etiology of progressive disorders, including cancer, has fostered incremental efforts on drug discovery programs over …

Nov 13, 2024 · The kinase inhibitors are a large group of unique and potent antineoplastic agents which specifically target protein kinases that are altered in cancer cells and that account for …

Jul 20, 2023 · Tyrosine kinase inhibitors are particularly important agents because these high-affinity cell surface receptors play a critical role in the progression of many cancers. Tyrosine …

Some kinase inhibitors are used to treat cancer. A substance that blocks a type of enzyme called a kinase. Human cells have many different kinases, and they help control important functions, …

Mar 26, 2025 · Delve into the kinase inhibitors' diverse landscape, from cancer breakthroughs to autoimmune disease innovations.

Nov 13, 2024 · The kinase inhibitors are a large group of unique and potent antineoplastic agents which specifically target protein kinases that are altered in cancer cells and that account for …

Feb 19, 2018 · These kinase inhibitors have achieved a significant increase in patient survival rate in myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST), thus translating basic …