KIF18A is a plus-end directed motor protein, and migrates to the plus ends of the spindle during early mitosis. It first accumulates there during prophase and metaphase, and is depleted …

Dec 27, 2023 · Here, we show that inhibitors of the KIF18A motor protein activate the mitotic checkpoint and selectively kill chromosomally unstable cancer cells.

Jan 2, 2025 · We identify and validate KIF18A, a mitotic kinesin, as a vulnerability of chromosomally unstable cancer cells. Knockdown of KIF18A leads to mitotic defects and …

May 29, 2024 · VLS-1488 is an oral small molecule inhibitor of KIF18A that is being examined in an open-label, phase I/II, first-in-human study evaluating the safety, tolerability, …

Jan 24, 2024 · Pharmacological inhibition of the mitotic kinesin KIF18A selectively exploits a mitotic vulnerability for which cancer models with CIN are enriched, which leads to robust anti …

Mar 30, 2025 · KIF18A (Kinesin Family Member 18A) is a Protein Coding gene. Diseases associated with KIF18A include Asbestosis and Goldberg-Shprintzen Syndrome. Among its …

Jun 2, 2022 · Background: KIF18A is a kinesin assisting chromosome congression and alignment during mitosis. It is nonessential in normal, euploid cell division but essential for a subset of …

Nov 24, 2024 · Kinesin-like protein 18A (KIF18A) is a member of the kinesin family of molecular motor proteins, which utilise energy from the hydrolysis of adenosine triphosphate (ATP) to …

Feb 8, 2023 · Univariate and multivariate regression analysis confirmed KIF18A as an independent prognostic factor for LIHC and PAAD. The mutation frequency of KIF18A is the …

Sep 17, 2024 · Structure–activity relationship (SAR) study led to the discovery of compound 16 with an alkenyl motif, a highly potent KIF18A inhibitor, which displayed a favorable …