Ketolides are antibiotics belonging to the macrolide group. Ketolides are derived from erythromycin by substituting the cladinose sugar with a keto-group and attaching a cyclic carbamate group in the lactone ring. [1] . These modifications give ketolides much broader spectrum than other macrolides.

Telithromycin, the first ketolide antibacterial agent to undergo clinical development, has enhanced binding to bacterial ribosomal RNA. Through its unique structure, telithromycin retains activity against resistant respiratory pathogens and has shown high efficacy in …

Ketolides are a new class of macrolides designed particularly to combat respiratory tract pathogens that have acquired resistance to macrolides. The ketolides are semi-synthetic derivatives of the 14-membered macrolide erythromycin A, and retain the erythromycin macrolactone ring structure as well as the D-desosamine sugar attached at position 5.

La telitromicina es el primer antibiótico de esta nueva clase (ketolidos) en ser aprobada por la Agencia de Drogas y Alimentos de los Estados Unidos (FDA) para el tratamiento de adultos con infecciones del tracto respiratorio.

Sep 16, 2012 · Ketolides are a new class of semi-synthetic agents derived from erythromycin A and designed to offer activity for the treatment of upper and lower tract respiratory infections, including those caused by resistant strains.

Una nueva generación de antimicrobianos aparece en la literatura internacional con la denominación de ketólidos aunque en rigor debemos llamarlos cetólidos. Son derivados de los macrólidos de 14 átomos, concretamente derivados semi sintéticos de eritromicina A y se caracterizan por la incorporación en su molécula de un radical cetónico 1.

Dec 18, 2012 · Ketolides are structurally related to macrolides and were developed to overcome macrolide resistance, while sharing pharmacodynamic and pharmacokinetic characteristics. However, until now, there have been no comprehensive reviews of the comparative pharmacokinetics of macrolides and ketolides.

File:Telithromycin.png Telithromycin. Ketolides are antibiotics belonging to the macrolide group. Ketolides are derived from erythromycin by substituting the cladinose sugar with a keto-group and attaching a cyclic carbamate group in the lactone ring. These modifications give ketolides much broader spectrum than other macrolides. Moreover, …

May 1, 2005 · Clinical trials have demonstrated that telithromycin 800 mg QD for 5 to 10 days is effective in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic...

Los macrólidos y cetólidos son familias de antibióticos que comparten el mismo mecanismo de acción. Las dos se unen a distintas bases del centro peptidiltransferasa del ARNr 23S.