Keratin, type II cytoskeletal 8 also known as cytokeratin-8 (CK-8) or keratin-8 (K8) is a keratin protein that is encoded in humans by the KRT8 gene. It is often paired with keratin 18. Antibodies to CK8 (e.g. CAM 5.2) can be used to differentiate lobular carcinoma of the breast from ductal carcinoma of the breast. [5] .

Mar 30, 2025 · KRT8 (Keratin 8) is a Protein Coding gene. Diseases associated with KRT8 include Cryptogenic Cirrhosis and Cirrhosis, Familial . Among its related pathways are Keratinization and Nervous system development .

Aug 26, 2021 · Keratin 8 and keratin 18 (K8/K18) are intermediate filament proteins that form the obligate heteropolymers in hepatocytes and protect the liver against toxins. The mechanisms of protection include the regulation of signaling pathway associated with cell survival.

A small molecule chaperone rescues keratin-8 mediated trafficking of misfolded podocin to correct genetic Nephrotic Syndrome. Keratin 8 is a scaffolding and regulatory protein of ERAD complexes. Keratin 8 Is an Inflammation-Induced and Prognosis-Related Marker for Pancreatic Adenocarcinoma.

Sep 2, 2016 · Here we report that down-regulation of CK8 in mice enhanced TLR-mediated responses, rendering mice more susceptible to lipopolysaccharide (LPS)-induced endotoxin shock and Escherichia coli –caused...

Keratin 8 is one of the major intermediate filament proteins present in intestinal enterocytes of patients with IBD. So, mice deficient for Keratin 8 develop colonic hyperplasia and colitis due to a primary epithelial rather than immune cell defect.

Keratin 8 Is an Inflammation-Induced and Prognosis-Related Marker for Pancreatic Adenocarcinoma. Xiong F, Guo T, Wang X, Wu G, Liu W, Wang Q, Wang B, Chen YXiong F, et al. Dis Markers, 2022. PMID 35958278.

Jul 27, 2022 · Keratin 8 (KRT8) is an important member of the keratin protein family and plays a role in regulating the cellular response to stress stimuli and mediating inflammatory reactions. However, the role of KRT8 in pancreatitis and PDAC is still poorly understood.

Keratin 8 (K8) and keratin 18 (K18) are the most common and characteristic members of the large intermediate filament gene family expressed in ‘simple’ or single layer epithelial tissues of the body.

Aug 12, 2022 · CK8 shows strong homology with the corresponding bovine, mouse, and Xenopus proteins. The human and mouse CK8 share about 82% identity in the N-terminal head domain, 95% identity in the alpha helical rod domain, and 67.5% identity in the C-terminal tail.