Keratin 20, often abbreviated CK20, is a protein that in humans is encoded by the KRT20 gene. [5][6][7] Keratin 20 is a type I cytokeratin. It is a major cellular protein of mature enterocytes and goblet cells and is specifically found in the gastric and intestinal mucosa. [8]

Feb 9, 2025 · High cytokeratin 20 expression is associated with invasive histological phenotype in poorly differentiated colorectal adenocarcinoma. Its association with clinical stage indicates that CK20 might have prognostic value as a marker for detection of circulating CRC cells.

Mar 30, 2025 · KRT20 (Keratin 20) is a Protein Coding gene. Diseases associated with KRT20 include Merkel Cell Carcinoma and Gastrointestinal Carcinoma . Among its related pathways are Keratinization and Nervous system development .

Colorectal cancer cells characteristically show strong expression of keratin 20 (K20) and lack expression of keratin 7 (K7).

Cytokeratin 20 (CK20) is a low-molecular-weight cytokeratin, which is expressed in normal glands as well as tumors of the gastrointestinal (GI) epithelium, urothelium, and skin stem cells that give rise to Merkel cell carcinomas. From: Abeloff's Clinical Oncology (Sixth Edition), 2020

Nov 27, 2024 · Identifying KRT20 as a Potential Key Gene in Lymphatic Metastasis of Head and Neck Squamous Cell Carcinoma.

Feb 10, 2009 · Keratin 20 (KRT20), a member of the intermediate filament and a well-known marker of intestinal differentiation, was initially identified as one of the genes likely to be directly regulated by CDX1. CDX1 and KRT20 mRNA expression were significantly correlated in a panel of 38 colorectal cancer cell lines.

Using selective antibodies against a newly described CK, number 20--originally found in intestinal epithelium and Merkel cell carcinomas--in comparison to a key protein of neuroendocrine cells, chromogranin A, we established CK 20 as a specific Merkel cell marker in …

Keratin 20 is a recently identified keratin protein distributed particularly in the epithelial cells of the gastrointestinal tract. In this study, keratin 20 was immunohistochemically evaluated in 788 epithelial tumors of different organs.

Nov 23, 2023 · Clinical resource with information about KRT20, Identification of 15 loci influencing height in a Korean population., and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.