Mar 15, 2000 · Using the KEN box as a template, we have identified cell cycle genes Nek2 and B99 as additional Cdh1-APC substrates. Mutation in the KEN box stabilizes all three proteins …

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The three main degrons that the APC/C interacts with are destruction box (also known as D box), the KEN box, and the ABBA motif. Most APC targets contain the D and the KEN box. These …

Sep 9, 2001 · We demonstrate that Hsl1p contains both a destruction box (D box) and a KEN box motif that are necessary for Hsl1p turnover with either APC Cdc20 or APC Cdh1. In …

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Nov 24, 2010 · Selection of APC/C targets is achieved through recognition of destruction motifs, predominantly the destruction (D)-box 3 and KEN (Lys-Glu-Asn)-box 4.

Jan 9, 2008 · Here we report new KEN-box candidates in cell cycle proteins. While annotating entries of the D-box and KEN-box for ELM, the Eukaryotic Linear Motif database (Puntervoll et …

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Jul 22, 2016 · We used an in vivo yeast assay to compare the G 1 degradation rate of 15 known substrates of the APC/C co-activator Cdh1 under normal conditions and conditions that impair …

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