KAP1 Protein: An Enigmatic Master Regulator of the Genome
In this minireview, we discuss how KAP1 might execute such pleiotropic effects, focusing on genomic targeting mechanisms, protein-protein interactions, specific post-translational …
TRIM28 - Wikipedia
Tripartite motif-containing 28 (TRIM28), also known as transcriptional intermediary factor 1β (TIF1β) and KRAB-associated protein-1 (KAP1), is a protein that in humans is encoded by the …
The ATM substrate KAP1 controls DNA repair in heterochromatin ...
KAP1 is a heterochromatin protein and co-repressor which binds to HP1 during gene silencing, but is also robustly phosphorylated by ATM at serine 824 in response to DNA damage. The …
KAP1/TRIM28: Transcriptional Activator and/or Repressor of
Feb 23, 2022 · We first summarize the discovery of KAP1 repression of endogenous retroviruses during development. We then deliberate evidence in the literature suggesting KAP1 is both an …
The ATM substrate KAP1 controls DNA repair in heterochromatin ... - PubMed
KAP1 is a heterochromatin protein and co-repressor that binds to HP1 during gene silencing but is also robustly phosphorylated by Ataxia telangiectasia mutated (ATM) at serine 824 in …
KAP-1 Promotes Resection of Broken DNA Ends Not Protected by …
KRAB-associated protein 1 (KAP-1) (TRIM28) is a transcriptional repressor that modulates chromatin structure and has been implicated in the repair of DNA DSBs in heterochromatin. …
KAP-1 phosphorylation regulates CHD3 nucleosome remodeling …
Jun 5, 2011 · KAP-1 poses a substantial barrier to DNA double-strand break (DSB) repair within heterochromatin that is alleviated by ATM-dependent KAP-1 phosphorylation (pKAP-1). Here …
KAP1 controls endogenous retroviruses in embryonic stem cells
Jan 14, 2010 · KAP1 (KRAB-associated protein 1, also known as tripartite motif-containing protein 28, TRIM28) represses genes by recruiting the histone methyltransferase SETDB1, …
SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific ...
Apr 4, 2002 · Here we report that the KAP-1 corepressor for the KRAB-ZFP superfamily of transcriptional silencers binds to SETDB1, a novel SET domain protein with histone H3-K9 …
[KAP-1, a scaffold protein in transcription regulation] - PubMed
KAP-1 (Alternative names: TIF1beta or TRIM28) is one member of transcriptional intermediary factors, which acts as a scaffold in many transcription regulation complexes.