The Kv7 family of voltage-gated potassium (K +) channels consists of five members (Kv7.1-7.5) encoded for by the KCNQ1-5 genes, respectively. Kv7 channels assemble as tetramers of identical or compatible α subunits, with each α subunit consisting of six transmembrane segments (S1–S6) and cytoplasmic N- and C-termini.

In this review, we focus on the family of the Kv7 channel encoded by the KCNQ genes and explore their possible role in cardiovascular disease (CVD) and the risk factors hypertension (HT), obesity and diabetes.

Tomb KV7 was the tomb of Ramesses II ("Ramesses the Great"), an ancient Egyptian pharaoh during the Nineteenth Dynasty. It is located in the Valley of the Kings opposite the tomb of his sons, KV5, and near to the tomb of his son and successor Merenptah, KV8.

Kv7 (KCNQ) channels are non-inactivating voltage-gated potassium channels, originally called M-channels, and are expressed by KCNQ genes.

Nov 1, 2005 · Mutations in Kv7 genes cause neurological disorders such as epilepsy and deafness. Kv7/M channels are inhibited by neurotransmitters that act on receptors coupled to the G protein G q....

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This symposium will showcase the myriad aspects of Kv7 research, with emphasis on emerging research areas. Contributions from leading academics and pharmaceutical company representatives will provide a programme that will stimulate all attendees irrespective of their interest in these fascinating and enigmatic channels.

He was the co-organiser for the 1 st International conference on Kv7 channels in Naples, 12-14 th September 2019. He became a Senior Fellow of the Higher Education Academy in April 2022. He was given a prestigious Honorary Fellowship by the …

Kv7 channels are unique among K+ channels, since four out of the five channel subtypes have well-documented roles in the development of human diseases. They have distinct physiological functions in the heart and in the nervous system, which can be ascribed to …

BHV-7000 is a potent, selective activator of Kv7.2/7.3 potassium channels, a clinically validated target to regulate the hyperexcitable state in epilepsy. Increasing evidence also suggests the potential for Kv7.2/7.3 activators to treat neuropsychiatric and pain disorders.