Krüppel-like factor 4 (KLF4; gut-enriched Krüppel-like factor or GKLF) is a member of the KLF family of zinc finger transcription factors, which belongs to the relatively large family of SP1 …

Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor that regulates diverse cellular processes such as cell growth, proliferation, and …

Mar 30, 2025 · KLF4 (KLF Transcription Factor 4) is a Protein Coding gene. Diseases associated with KLF4 include Hematologic Cancer and Glioma Susceptibility 1. Among its related …

KLF4 plays a promoter role in tumorigenesis and development, or tumor suppressor as a context-dependent anti- and pro-inflammatory factor. KLF4 over-expression increases CD8+T cell …

Apr 8, 2023 · In this review, we will summarize the structural and functional aspects of KLF4, with a focus on KLF4 as a clinical biomarker and therapeutic target in different types of tumors.

Mar 26, 2025 · KLF4 regulates trophoblast function and associates with unexplained recurrent spontaneous abortion. KLF4-induced upregulation of SOCS1 ameliorates myocardial …

Klf4, also known as gut-enriched Krüppel-like factor (GKLF), acts as a transcriptional activator or repressor depending on the promoter context and/or cooperation with other transcription factors.

Krüppel-like factor 4 is a zinc finger-type transcription factor expressed in a variety of tissues, including the epithelium of intestine and the skin, where it is important in differentiation and cell …

May 5, 2017 · Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor that regulates diverse cellular processes such as cell growth, proliferation, …

Mar 14, 2016 · By using genetically engineered mouse models of mutant KrasG12D and klf4 alterations, and molecular biology analyses, we demonstrate that KLF4 is a ductal fate …