KLF2 - Wikipedia
Krüppel-like Factor 2 (KLF2), also known as lung Krüppel-like Factor (LKLF), is a protein that in humans is encoded by the KLF2 gene on chromosome 19.
KLF2 maintains lineage fidelity and suppresses CD8 T cell …
KLF2 knockout (KO) T cells aberrantly acquired distinct features of exhaustion during acute LCMV infection. This included impaired effector and memory differentiation and function during both …
KLF2 Gene - GeneCards | KLF2 Protein | KLF2 Antibody
Mar 30, 2025 · KLF2 (KLF Transcription Factor 2) is a Protein Coding gene. Diseases associated with KLF2 include Hermansky-Pudlak Syndrome 2 and Leukemia, Acute Lymphoblastic. …
KLF2 maintains lineage fidelity and suppresses CD8 T cell …
Jan 2, 2025 · KLF2 was required to suppress the exhaustion-promoting TF TOX and to enable the TF TBET to drive effector differentiation. KLF2 was also necessary to maintain a polyfunctional …
Krüppel-like Factor 2 (KLF2) in Immune Cell Migration
Oct 13, 2021 · Krüppel-like factor 2 (KLF2), a transcription factor of the krüppel-like family, is a key regulator of activation, differentiation, and migration processes in various cell types. In this …
KLF2-dependent transcriptional regulation safeguards the heart …
This study provides the first evidence that transcription factor KLF2 serves as a negative regulator of cardiac hypertrophy. Our findings highlight the therapeutic potential of enhancing KLF2 …
KLF2 KLF transcription factor 2 [ (human)] - National Center for ...
Feb 9, 2025 · KLF2 Mediates the Suppressive Effect of Laminar Flow on Vascular Calcification by Inhibiting Endothelial BMP/SMAD1/5 Signaling. KLF2 inhibits cancer cell migration and …
KLF2 and KLF4 control endothelial identity and vascular integrity
Inducible endothelial-specific deletion of Klf2 and/or Klf4 reveals that a single allele of either gene is sufficient for survival, but absence of both (EC-DKO) results in acute death from myocardial …
Klf2 Is an Essential Factor that Sustains Ground State Pluripotency
Klf2 is critical for ground state pluripotency. Klf2 is negatively regulated by Mek/Erk signaling at the posttranslational level. Erk2 directly interacts with and phosphorylates Klf2. …
Deciphering the role of Klf2 in CD8 T cell differentiation and ...
May 1, 2024 · These insights underscore the differential transcriptional and epigenetic regulation of Klf2, presenting a novel mechanism that influences the cell fate decision of CD8 T cells …