In the KKS, vasopermeability is associated with bradykinin and desArg 9-bradykinin signalling via the receptors B2R and B1R, respectively, and in the complement system with C5a signalling …

Aug 14, 2017 · C5a, which is released from C5 via cleavage by serine proteases, is critical for autoantibody-induced arthritis (43, 44). As Kal is a serine protease that shares a consensus …

In this Review, we describe the RAS, the complement system and the plasma KKS/contact system and their role in inflammation, with a particular focus on the mechanisms of crosstalk …

The kallikrein–kinin system (KKS) is proposed to act as a counter regulatory system against the vasopressor hormonal systems such as the renin-angiotensin system (RAS), aldosterone, and …

Sep 1, 2019 · We demonstrate that blockade of the kallikrein-kinin system, by blocking kinin B1 and/or B2 receptors, or by incubation with C1 inhibitor, decreases complement deposition on …

May 7, 2024 · This was specifically supported by the counterevidence that the addition of the inhibitors of the KKS (i.e., CTI or aprotinin) significantly attenuated PM-induced decreases of …

Aug 7, 2023 · In this article, we present 4 families with HAE-nC1-INH clinical phenotype and CPN deficiency. The biological parameters and selected genes related to kallikrein-kinin system …

Nov 10, 2021 · In the KKS, vasopermeability is associated with bradykinin and desArg 9-bradykinin signalling via the receptors B2R and B1R, respectively, and in the complement …

KKS activation activates prekallikrein (pKal) and factor XII (FXII) cleavage of high-MW kininogen (HK) to release bradykinin. Kal also activates monocytes to promote proinflammatory …

C5a is a protein fragment released from cleavage of complement component C5 by protease C5-convertase into C5a and C5b fragments.