K562 cells were the first human immortalised myelogenous leukemia cell line to be established. K562 cells are of the erythroleukemia type, and the cell line is derived from a 53-year-old female chronic myelogenous leukemia patient in blast crisis.

K-562 are lymphoblast cells isolated from the bone marrow of a 53-year-old chronic myelogenous leukemia patient. The K-562 cell line is widely used in immune system disorder and immunology research.

Here, we have characterized K562 cells focusing on the karyotype of cells in prolonged culture, regulation of expression of TfR in wildtype (WT) and doxorubicin-resistant cells, and responses to histone deacetylase inhibition (HDACi).

The K562 cell line exhibits pervasive aneuploidy (Fig. 2A). Analysis of 20 individual K562 cells using GTW banding showed that all cells demonstrated a near-triploid karyotype and are characterized by multiple structural abnormalities.

Feb 7, 2025 · K562 cells are classified as an erythroleukemia cell line, exhibiting properties of both erythroid and leukemic cells. Their large size, round shape, high nucleus-to-cytoplasm ratio, and chromosomal abnormalities, including the Philadelphia chromosome, are …

Complete karyotype characterization of the K562 cell line by combined application of G-banding, multiplex-fluorescence in situ hybridization, fluorescence in situ hybridization, and comparative genomic hybridization.

Feb 7, 2011 · K562 is an erythroleukemia cell line that lacks HLA antigen expression. K562 cells have been shown to provide a cell contact-dependent co-stimulatory signal, enhancing the expansion of NK cells [52]. Combined with IL-2 and IL-15, up to 300-fold expansions have been reported [53]. It was with the enforced expression of specific co-stimulatory ...

The human leukemia cell line K562 represents an attractive platform for creating artificial antigen presenting cells (aAPC). It is readily expandable, does not express HLA class I and II and can be stably transduced with various genes.

Fixed gene-modified K562 can serve as effective aAPC to expand CMV-specific cytotoxic T lymphocytes for therapeutic use in patients after stem cell transplantation. Our findings have implications for broader understanding of the immune evasion mechanisms used by …

Oct 1, 2017 · Our results confirm the existence of major chromosomal aberrations in K562 cell line but we describe new mutations in several oncogenes other than BCR-ABL1 fusion gene. This confirms a high level of genomic instability in the blastic phase of …