Tyrosine kinase inhibitor (TKI) resistance is a major problem in chronic myeloid leukemia (CML). We generated a TKI-resistant K562 sub-population, K562-IR, under selective imatinib-mesylate...

Does anyone have experience with the markers expressed on K562 cells? I have checked DSMZ and when I stain my cells with the markers stated that K562 should be positive for and run the profile on...

K-562 are lymphoblast cells isolated from the bone marrow of a 53-year-old chronic myelogenous leukemia patient. The K-562 cell line is widely used in immune system disorder and immunology research. Please fill out the form below to sign up for notification when the product becomes in stock. You were successfully signed up for notification.

To ensure growth inability of K562 cells, we irradiated the cells with X-ray, followed by the evaluation of post-irradiative cell proliferation by cell number count, viability assays using Trypan blue and PI staining. Firstly, K562 cells were treated with 50, 75, 100, 125, 150 Gy X-ray.

This study concerns the analysis of the modulation of Chronic Myeloid Leukemia (CML) cell model K562 transcriptome following transfection with the tumor suppressor gene encoding for Protein ...

Flow cytometry of cell surface markers of K562 and K562-IR cells. CD45, CD33, CD65, CD146 hematologic marker expressions are reduced in K562-IR cells. CD44 and SSEA-4 have increased expression while no difference was observed in CD34 and CD38.

Fixed gene-modified K562 cells can serve as effective aAPC to expand CMV-specific CTL for therapeutic use in patients after stem cell transplantation. Our findings have implications for broader understanding of the immune evasion mechanisms used by leukemia and other tumors. Keywords: Artificial APC, Cytomegalovirus, Cytotoxic T cell, Fixation.

Here, we have characterized K562 cells focusing on the karyotype of cells in prolonged culture, regulation of expression of TfR in wildtype (WT) and doxorubicin-resistant cells, and responses to histone deacetylase inhibition (HDACi).

Feb 7, 2025 · K562 cells are classified as an erythroleukemia cell line, exhibiting properties of both erythroid and leukemic cells. Their large size, round shape, high nucleus-to-cytoplasm ratio, and chromosomal abnormalities, including the Philadelphia chromosome, are …

May 1, 2007 · To facilitate the therapeutic application of antigen-presenting cells (APCs), we have developed a cell-based artificial APC (aAPC) system by engineering K562 cells with lentiviruses to direct the stable expression and secretion of a variety of co …