The sodium-calcium exchanger (often denoted Na+/Ca2+ exchanger, exchange protein, or NCX) is an antiporter membrane protein that removes calcium from cells. It uses the energy that is stored in the electrochemical gradient of sodium (Na +) by allowing Na + to flow down its gradient across the plasma membrane in exchange for the countertransport ...

The plasma-membrane homeostasis Na+/Ca2+ exchangers (NCXs) mediate Ca2+ extrusion/entry to dynamically shape Ca2+ signaling/in biological systems ranging from bacteria to humans. The NCX gene orthologs, isoforms, and their splice variants are ...

Mar 1, 2020 · In this review, we will specifically focus on the Na+ /Ca 2+ exchanger (NCX) – one of the master regulators of cell Ca 2+ cycling – and discuss recent observations that point to a key role of the NCX Ca 2+ balancing activity in controlling cell energy metabolism and mitochondrial Ca 2+ homeostasis.

Oct 4, 2023 · Na + /Ca 2+ exchangers (NCX) transport Ca 2+ in or out of cells in exchange for Na +. They are ubiquitously expressed and play an essential role in maintaining cytosolic Ca 2+ homeostasis.

Molecular silencing/overexpression of NCX in cellular systems and organ-specific KO mouse models provided useful information on the contribution of distinct NCX variants to cellular and systemic functions under various pathophysiological conditions.

Dec 15, 2023 · Crystal structures of bacterial NCX from archaebacterial Methanococcus jannaschii (mjNCX) reveal the arrangement of ten transmembrane helices and four ion binding sites formed by two so-called α-repeats which are accessible via two passageways (Liao et al, 2012; Liao et al, 2016).

Jun 12, 2003 · Increased Na + -Ca 2+ exchange (NCX) activity in heart failure and hypertrophy may compensate for depressed sarcoplasmic reticular Ca 2+ uptake, provide inotropic support through reverse-mode Ca 2+ entry, and/or deplete intracellular Ca 2+ stores.

Oct 25, 2012 · The Na+/Ca2+ exchanger (NCX) is a plasma membrane protein that can switch Na+ and Ca2+ in either direction to maintain the homeostasis of intracellular Ca2+. A family of three genes (NCX1, NCX2, and NCX3) has been identified in …

Na + /Ca 2+ exchangers (NCX) transport Ca 2+ in or out of cells in exchange for Na +. They are ubiquitously expressed and play an essential role in maintaining cytosolic Ca 2+ homeostasis.

Jun 25, 2018 · Na + -Ca 2+ exchanger (NCX) isoforms constitute the major cellular Ca 2+ extruding system in neurons and microglia. We herein investigated the role of NCX isoforms in the pathophysiology of...