JNK (c-Jun N-terminal kinase) is a member of the MAPK (mitogen-activated protein kinase) family that regulates a range of biological processes implicated in tumorigenesis and neurodegenerative disorders.

Jun N-terminal kinases (JNKs) and p38 mitogen-activated protein kinases (MAPKs) have important roles in the signalling mechanisms that orchestrate cellular responses to many types of...

Among the central pathways activated in immune cells are the MAP kinases (MAPKs), a family of serine/threonine kinases. The four well characterized subfamilies of MAPKs include: the extracellular signal-regulated kinases (ERK1/2), c-Jun NH 2 -terminal kinases (JNK-1/2/3), p38 (p38α/β/γ/δ) and ERK5.

As a member of the mitogen-activated protein kinase (MAPK) family, JNK is also known as stress-activated kinase (SAPK) because it can be activated by extracellular stresses including growth factor, UV irradiation, and virus infection.

Oct 30, 2023 · Purpose: Mitogen-activated protein kinases (MAPK), specifically the c-Jun N-terminal kinase (JNK)-MAPK subfamily, play a crucial role in the development of various cancers, including hepatocellular carcinoma (HCC). However, the specific roles of JNK1/2 and their upstream regulators, MKK4/7, in HCC carcinogenesis remain unclear.

Three groups of MAP kinases can be defined: ERK (extracellular signal-regulated kinase); JNK (c-Jun N-terminal kinase); and p38 MAP kinases. These pathways can be activated by many stimuli, including growth factors, inflammatory cytokines, and a wide spectrum of cellular stresses.

Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family members function in a cell context-specific and cell type-specific manner to integrate signals that affect proliferation, differentiation, survival and migration.

Mar 1, 2002 · MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. At least three MAPK families have been...

Mar 28, 2014 · The Mitogen Activated Protein Kinase (MAPK) signaling plays a critical role in the outcome and the sensitivity to anticancer therapies. Activated MAPK can transmit extracellular signals to regulate cell growth, proliferation, differentiation, migration, apoptosis and so on.

c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family members integrate signals that affect proliferation, differentiation, survival, and migration in a cell context- and cell type-specific way.