Nov 20, 2014 · JNK activation increases spontaneous action potential firing of AgRP cells and causes both neuronal and systemic leptin resistance. Similarly, activation of IKK2 signaling in AgRP neurons also increases firing of these cells but fails to cause obesity and leptin resistance.

Feb 4, 2020 · Here we identify a novel and critical function of IKK2 and its co-factor NEMO in the activation of oncogenic c-Jun N-terminal kinase (JNK) signaling, induced by the latent membrane protein 1...

Dec 1, 1999 · Both IKKβ and JNK2 are essential for efficient induction of type I IFN and other cytokines in response to viral infection or dsRNA. This study establishes a general role for these kinases in activation of innate immune responses.

Jul 19, 2001 · We find that the TAK1 kinase complex phosphorylates and activates IKK in a manner that depends on TRAF6 and Ubc13–Uev1A. Moreover, the activity of TAK1 to phosphorylate MKK6, which activates the...

The IKK kinase complex is the core element of the NF-κB cascade. It is essentially made of two kinases (IKKα and IKKβ) and a regulatory subunit, NEMO/IKKγ. Additional components may exist, transiently or permanently, but their characterization is ...

The inhibitor of nuclear factor-κB (IκB) kinase (IKK) complex is the master regulator of the NF-κB signaling pathway. The activation of the IKK complex is a tightly regulated, highly stimulus-specific, and target-specific event that is essential for ...

Feb 12, 2020 · JNK pathway has crosstalk with IKK/NF-κB and can be up-regulated by inhibition of IKK/NF-κB (9, 23). Function of JNK pathway is complicate and varies in different cell types, which induces apoptosis in many cell types but stimulates cell proliferation in epidermal cells .

Nov 20, 2014 · The data reveal distinct effects of c-Jun N-terminal kinase (JNK)- and inhibitor of nuclear factor kappa-B kinase (IKK)-dependent signaling in AgRP neurons, which cooperate in the manifestation of the metabolic syndrome.

Increased blood free fatty acids (FFAs), often observed in obesity, leads to impaired insulin action, and promotes the development of insulin resistance and Type 2 diabetes mellitus (T2DM). JNK, IKK-NF-κB, and STAT3 are known to be involved in skeletal muscle insulin resistance.

Aug 4, 1998 · However overexpression of NIK can lead to JNK activation whereas overexpression of MEKK1 can lead to IKK activation (Fig. 2B). These results are in complete agreement with all published comparisons of the effect of these MAPKKKs on NF …