Sep 1, 2021 · Further, the downstream activation and regulation of AP-1 transcription factors could be through stress activated c-Jun – N terminal Kinase (JNK) Mitogen Activated Protein Kinases (MAPKs) which downregulated both Jun and Fos mRNA transcripts in areca nut extract exposed KB cells.

c-Jun N-terminal kinases (JNKs), were originally identified as kinases that bind and phosphorylate c-Jun on Ser -63 and Ser-73 within its transcriptional activation domain. They belong to the mitogen-activated protein kinase family, and are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock.

Mar 1, 2002 · MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. At least three MAPK families have been...

We show that increased Jun N-terminal kinase (JNK) signaling resulting from the loss of scribble promotes the movement of transformed cells to secondary sites. This effect requires Fos-dependent transcriptional activation of a matrix metalloprotease gene mmp1 downstream of JNK.

May 5, 2022 · c-Fos expression is induced following stimulation of JNK (Cavigelli et al., 1995, Whitmarsh et al., 1997). To specifically activate the protein kinase JNK, we expressed the catalytic domain of MEKK1 in HEK293 cells ( Fig. 5 A) using lentiviral gene transfer.

Our results identify FOS-1 as a transcriptional activator mediating age-invariant contributions of KGB-1, including a regulatory loop of KGB-1 signaling, but also stress the importance of DAF-16 as a mediator of age-dependent contributions.

Transcription factor Jun is a protein that in humans is encoded by the JUN gene. c-Jun, in combination with protein c-Fos, forms the AP-1 early response transcription factor.

Jan 1, 2017 · FOS-1 is an essential activator for KGB-1-dependent age-invariant gene expression. FOS-1 mediates a regulatory feedback loop in KGB-1 signaling. FOS-1 acts in parallel to DAF-16 in mediating KGB-1-dependent gene expression. DAF-16 mediates age-dependent contributions of KGB-1 to stress resistance.

Oct 17, 2022 · Protein phosphorylation is a major regulatory mechanism of cellular signalling. The c-JUN proto-oncoprotein is phosphorylated at four residues within its transactivation domain (TAD) by the JNK...

Nov 4, 1999 · This review focuses on recent developments in understanding how activation of JNK and c-Jun contributes to different cellular responses.