Pivotal Role of Antibody and Subsidiary Contribution of CD8
JEV infection resulted in extensive CD8 + T cell activation, judged by upregulation of surface markers CD69 and CD25 and cytokine production after stimulation with a JEV NS4B protein …
Japanese encephalitis virus–primed CD8 - National Center for ...
Sep 9, 2020 · Chen et al. show that Japanese encephalitis virus (JEV)–elicited CD8 + T cells and antibodies play protective and pathogenic roles in Zika virus–infected wild-type C57BL/6 mice, …
Japanese encephalitis virus-primed CD8+ T cells prevent antibody ...
Sep 7, 2020 · We show that sera and IgG from JEV-vaccinated humans and JEV-inoculated mice cross-reacted with ZIKV, exacerbated lethal ZIKV infection upon transfer to mice, and …
CD8 T cells protect adult naive mice from JEV-induced morbidity …
Feb 2, 2017 · Our data show that effector CD8 T cells play a protective role during primary infection possibly by preventing the breach in BBB and neuronal damage. Japanese …
Human T cell responses to Japanese encephalitis virus in health …
Healthy donors exposed to Japanese encephalitis (JE) virus show a CD8 + T cell response that cross reacts with other flaviviruses. Patients that recovered from JE show a CD4 + T cell …
Myeloid-Derived Suppressor Cells Induce Exhaustion-Like CD8
Our results demonstrated that JEV infection significantly elevated the expression of PD-1 and TIM-3 on CD8 + T cells, which are markers of T cell exhaustion, leading to inhibited function …
Multifront assault on antigen presentation by Japanese …
Aug 1, 2010 · In this study, we found that JEV induced the subversion of CD8(+) T cell responses in a transient manner that was closely correlated with viral multiplication. Subsequently, …
Identification of Immune Responses to Japanese Encephalitis Virus ...
Feb 12, 2020 · Both CD8+ and CD4+ T cells have been shown to play an important role in protection against DENV, JEV and Zika virus (5, 9–12). Individuals who were naturally …
Japanese encephalitis virus–primed CD8 - Rockefeller University …
Strikingly, JEV-elicited CD8 + T cells are able to attenuate the pathogenic effects of JEV-immune Abs in exacerbating ZIKV infection. These results underscore the importance of a balanced …
PD1+CCR2+CD8+ T Cells Infiltrate the Central Nervous System …
JEV infection dramatically enhanced the expression of programmed death 1 (PD-1) on infiltrating CD8 + T cells in the brain, as compared to that on peripheral CD8 + T cells in the spleen. This …