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See all on WikipediaJAK-STAT signaling pathway - Wikipedia
JAK-STAT signalling is made of three major proteins: cell-surface receptors, Janus kinases (JAKs), and signal transducer and activator of transcription proteins (STATs). Once a ligand (red triangle) binds to the receptor, JAKs add phosphates (red circles) to the receptor. See more
The JAK-STAT signaling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death, and tumor formation. The pathway communicates information from … See more
Given that many JAKs are associated with cytokine receptors, the JAK-STAT signalling pathway plays a major role in cytokine receptor … See more
Given the importance of the JAK-STAT signalling pathway, particularly in cytokine signalling, there are a variety of mechanisms that cells possess to regulate the amount of … See more
The binding of various ligands, usually cytokines, such as interferons and interleukins, to cell-surface receptors, causes the receptors … See more
JAK-STAT signalling plays an important role in animal development. The pathway can promote blood cell division, as well as differentiation (the process of a cell becoming more … See more
Since the JAK-STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, … See more
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The JAK/STAT signaling pathway: from bench to clinic
Nov 26, 2021 · JAKs are noncovalently associated with cytokine receptors, mediate tyrosine phosphorylation of receptors, and recruit one or more STAT proteins. Tyrosine-phosphorylated …
- Author: Xiaoyi Hu, Jing Li, Maorong Fu, Xia Zhao, Wei Wang
- Publish Year: 2021
The JAK/STAT Pathway - PMC - PubMed Central (PMC)
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway mediates cellular responses to cytokines (e.g., IL-6) and growth factors (e.g., EGF).
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STAT3 Signaling Pathway in Health and Disease
The interleukin-6/Janus kinase (JAK)/STAT3 signaling axis is central to STAT3 activation, influencing tumor microenvironment remodeling, angiogenesis, immune evasion, and therapy …
Targeting the IL-6/JAK/STAT3 signalling axis in cancer
Novel inhibitors of the IL-6/JAK/STAT3 pathway, including STAT3-selective inhibitors, are currently in development. Herein, we review the role of IL-6/JAK/STAT3 signalling in the …
- Author: Daniel E. Johnson, Rachel A. O'Keefe, Jennifer R. Grandis
- Publish Year: 2018
The JAK-STAT pathway: from structural biology to cytokine …
Aug 21, 2024 · The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway serves as a paradigm for signal transduction from the extracellular environment to the …
JAK-STAT signaling pathway - Homo sapiens (human) - KEGG
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and …
JAK/STAT pathway: Extracellular signals, diseases, immunity, and ...
The JAK/STAT pathway has three components: cellular receptors, JAK protein, and STAT protein. The JAK family is a group of non-transmembrane tyrosine kinases, which is mainly composed …
Evolving cognition of the JAK-STAT signaling pathway: …
May 19, 2023 · The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway is an evolutionarily conserved signaling pathway that functions in several …
The JAK-STAT pathway at 30: Much learned, much …
Oct 13, 2022 · The JAK/STAT pathway regulates multiple cellular processes across organisms. Molecular details of signaling mechanisms have revealed insights into a range of human diseases.
