JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines.

JH1 is the kinase domain important for the enzymatic activity of the JAK and contains typical features of a tyrosine kinase such as conserved tyrosines necessary for JAK activation (e.g., Y1038/Y1039 in JAK1, Y1007/Y1008 in JAK2, Y980/Y981 in JAK3, and Y1054/Y1055 in Tyk2).

Oct 26, 2023 · Janus kinase (JAK) inhibitors work by slowing down the overactivity of the immune system that can lead to inflammation and pain. They do this by inhibiting the activity of one or more JAK enzymes (JAK1, JAK2, JAK3, and TYK2) found in the cell.

Mar 30, 2025 · JAK1 (Janus Kinase 1) is a Protein Coding gene. Diseases associated with JAK1 include Autoinflammation, Immune Dysregulation, And Eosinophilia and Breast Implant-Associated Anaplastic Large Cell Lymphoma.

May 12, 2004 · Janus kinases (Jaks) are non-receptor tyrosine kinases and were discovered in searches for novel protein tyrosine kinases using PCR-based strategies or low-stringency hybridization [1 - 6]. In mammals, the family has four members, Jak1, Jak2, Jak3 and Tyrosine kinase 2 (Tyk2).

In mice, the Jak1 gene is located on chromosome 4, Jak2 on chromosome 19, and Jak3 and Tyk2 on chromosome 8. Jaks are relatively large proteins containing more than 1,000 amino acids. Seven distinct Jak homology regions (JH) have been identified (JH1 to JH7), and these form the putative structural domains of the Jak family members (Fig. 1).

This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein.

Nov 26, 2021 · When cytokines bind to their receptors, JAK tyrosine kinases are activated and transmit regulatory signals. The JAK family has four main members, JAK1, JAK2, JAK3, and TYK2.

Here, we review the current knowledge of their physiological functions and the causative role of activating and inactivating JAK mutations in human diseases, including haematopoietic malignancies, immunodeficiency and inflammatory diseases.

Aug 24, 2022 · One, called Janus kinase 1 (JAK1), is a member of a new class of PTKs characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain--hence the name Janus.