Apr 1, 2025 · In this issue of the JCI, Sun, Zhang, and colleagues identified nonhistone ENSA-K63 lactylation as a critical regulator that inactivates PP2A, activates STAT3/CCL2 signaling, recruits tumor-associated macrophages (TAMs), and suppresses cytotoxic T cell activity.

Why submit your manuscript to the JCI? [Top of page] Broad readership and scope. Readers across a wide range of medical disciplines and sectors; basic and phase I/II clinical research articles in all biomedical specialties, including Immunology, Metabolism, Neuroscience, Oncology, Vascular biology, and many others. Open access.

Apr 1, 2025 · In this issue of the JCI, Zeng et al. delve into a pivotal mechanism underpinning this adaptability. They identified an important role for TNF receptor–associated factor 3 (TRAF3) in regulating lipid metabolism through its interaction with enoyl-CoA hydratase 1 (ECH1).

Submit a manuscript to the JCI and JCI Insight simultaneously using the Dual-Journal Submission option. View details here. You may transfer a manuscript from the preprint server bioRxiv or medRxiv for submission to the Journal.

Oct 1, 2024 · From the 1960s to 1980s, the quest to explain how this genetic disease caused the diverse manifestations accelerated. A 1962 JCI paper reported abnormal mucoproteins in CF urine as an early attempt to identify the molecular nature of the disease .

Example of a high-quality JCI figure [Top of page] The figure below is representative of the quality the Journal strives to achieve.

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Feb 15, 2024 · To the Editor: A recently published JCI paper revealed that cancer-associated fibroblasts (CAFs) are present in glioblastoma and are defined by the presence of 9 transcriptional markers . CAFs can form a barrier around cancer cells that prevents their detection by T cells ( …

The digital version of JCI This Month is free. See here for information about subscribing to the print version, which include online access to all JCI articles. What are the black and white squares for? You'll notice quick-response codes, or squares, in JCI This Month.

Dual-Journal Submission gives you the option to submit your work for consideration by both the JCI and JCI Insight. Dual-Journal Submission increases your opportunity to find the right home for your work within the JCI Family of Journals and streamlines the peer-review process.