This orthogonally-protected lysine derivative is based on the hindered Dde variant ivDde.

The problem can be avoided for peptides containing side-chain modified lysine by using ivDde-Lys(Fmoc)-OH instead of Fmoc-Lys(ivDde)-OH for incorporation of those residues. The use of the former allows side-chain modification of lysine to be accomplished during chain extension.

Fmoc-Lys(ivDde)-OH contains the iVDde group which can be orthogonally removed allowing for selective branching on the lysine side chain group.

Novel tool for the synthesis of branched, cyclic and modified peptides by Fmoc SPPS. Following introduction of this building block, the Fmoc group can be removed by treatment with piperidine in DMF enabling chain extension on the lysine side chain.

Fmoc-Lys (IvDde)-OH | C34H42N2O6 | CID 135443653 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

Fmoc-D-Lys (Ivdde)-OH | C34H42N2O6 | CID 135742620 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

Fmoc-Lys (ivDde)-OH is a protected derivative of the amino acid lysine, specifically designed for use in solid-phase peptide synthesis (SPPS), particularly in Fmoc (fluorenylmethyloxycarbonyl) chemistry. It is widely used for incorporating lysine into peptide sequences while allowing selective deprotection of the lysine side chain.

Mar 18, 2021 · 1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl (ivDde), an amino protecting group cleavad by 2% hydrazine hydrate in DMF. ivDde is more stable towards the repetitive piperidine treatments during Fmoc-SPPS than Dde.

Learn about an optimized protocol for automated synthesis and ivDde protecting group removal using the Initiator+ Alstra™ peptide synthesizer.

ivDde-D-Lys(Fmoc) is a lysine derivative featuring orthogonal protecting groups: the 9-fluorenylmethoxycarbonyl (Fmoc) group on the α-amino position and the ivDde [1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl] group on the ε-amino side chain.