Integrin alpha M - Wikipedia
Integrin alpha M (ITGAM) is one protein subunit that forms heterodimeric integrin alpha-M beta-2 (α M β 2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 …
ITGAM Gene - GeneCards | ITAM Protein | ITAM Antibody
Mar 30, 2025 · ITGAM (Integrin Subunit Alpha M) is a Protein Coding gene. Diseases associated with ITGAM include Systemic Lupus Erythematosus 6 and Neutropenia, Severe Congenital, X …
Deficiency of ITGAM Attenuates Experimental Abdominal Aortic Aneurysm ...
Mar 20, 2021 · Integrin αM (CD11b), which is encoded by the Integrin Subunit Alpha M (ITGAM) gene, is not only a surface marker of monocytes but also an essential adhesion molecule. In …
ITGAM is a risk factor to systemic lupus erythematosus and …
ITGAM has consistently been associated with susceptibility to systemic lupus erythematosus (SLE) in many ethnically diverse populations. However, in populations with higher Amerindian …
The CD11b-integrin (ITGAM) and systemic lupus erythematosus
Variations at the ITGAM gene, which encodes for the CD11b chain of the Mac-1 (alphaMbeta2; CD11b/CD18; complement receptor-3) integrin, is one of the strongest genetic risk factors for …
ITGAM: A Pivotal Regulator in Macrophage Dynamics and Cardiac …
The significant upregulation of Itgam in MAC2 post-CLP indicates a dynamic shift in this subtype's role during SIC progression. ITGAM, also known as CD11b, synergizes with the beta 2 chain …
Small Molecule Targeting ITGAM in Lupus - Lupus Research
Dr. Niewold and his collaborator Vineet Gupta at UTMB have developed a first-of-its-kind drug called ONT01, a twice-daily pill that targets a protein called integrin subunit alpha M (ITGAM or …
ITGAM integrin subunit alpha M [ Homo sapiens (human) ]
Jan 4, 2025 · A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of integrin, alpha M (ITGAM, CR3A) …
ITGAM protein expression summary - The Human Protein Atlas
Selective cytoplasmic expression in subset of immune cells and glial cells. Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.
ITGAM (human) | Gene Target - PubChem
Sep 14, 2016 · Gene target information for ITGAM - integrin subunit alpha M (human). Find diseases associated with this biological target and compounds tested against it in bioassay …