Learn how ISTURISA® (osilodrostat) helps patients with Cushing's disease reach and maintain normal cortisol levels.

ISTURISA is an oral tablet you take twice a day, with or without food. ISTURISA offers flexible dosing options and comes in 2 different strengths: 1 mg and 5 mg. Your healthcare provider may recommend you take a combination of different tablets, and adjust based on how you respond.

ISTURISA is proven to deliver significant and sustained cortisol control in the majority of patients with CD 3,4,a. a In the LINC 3 pivotal study, 86% (n=31/36) of patients achieved mean urine free cortisol (mUFC) ≤ upper limit of normal (ULN) vs 29% (n=10/34) with placebo (P<.001).During the open-label period, 66% (91/137) of patients had normal mUFC levels at Week 48.

6 ADVERSE REACTIONS Clinically significant adverse reactions that appear in other sections of the labeling include: • Hypocortisolism [see Warnings and Precautions (5.1)] • QT Prolongation [see Warnings and Precautions (5.2)] • Elevations in Adrenal Hormone Precursors and Androgens [see Warnings and Precautions (5.3)] 6.1 Clinical Trials Experience

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INDICATION(S) AND IMPORTANT SAFETY INFORMATION INDICATIONS AND USAGE. ISTURISA ® (osilodrostat) is a cortisol synthesis inhibitor indicated for the treatment of adult patients with Cushing’s disease for whom pituitary surgery is not an option or has not been curative.. IMPORTANT SAFETY INFORMATION. Hypocortisolism: ISTURISA lowers cortisol levels and can lead to hypocortisolism and ...

There are people out there who understand. Cushing’s Conversations will connect you with someone else who has Cushing’s disease and is managing it with ISTURISA ® (osilodrostat). Find the support you need with personal, 1:1 phone calls—and remember, you’re not alone.

Cushing’s Disease Overview Brochure A post-diagnosis information source to help patients understand their condition and the effects of living with CD. Download Isturisa Patient Brochure Help educate your patient on what to expect with ISTURISA. Download Symptom and Self-Monitoring Diary A useful tracking tool to help patients …

ISTURISA® (Osilodrostat) Phone:Patient Prescription Form Please select one: Newly Prescribed Patient Patient Currently on Isturisa® Fax: 855‐813‐2039 888-855-RARE (888-855-7273) Patient Information

b Information provided by the Nurse Educators is for educational purposes only and not intended to replace the advice of your healthcare provider. Our team will stay in touch throughout your therapy. Your enrollment in R.A.R.E. will be processed along with your prescription. However, if you have any questions, or would like to discuss how the program can help support your treatment, give us a ...