However, several isoform-specific or isoform-preferential reactions are known to occur within the CYP3A family, and some have clinical relevance. In recent years, important tool compounds have been developed that exploit subtle differences between CYP3A4 and CYP3A5, enabling evidence of isoform-specific catalytic activities to be obtained.

CYP3A is an enzyme subfamily in the cytochrome P450 (CYP) superfamily and includes isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate toward substrates and are unique in that these enzymes metabolize both endogenous ...

Cytochrome P450, family 3, subfamily A, also known as CYP3A, is a human gene locus. [2] [3] A homologous locus is found in mice. [4] The CYP3A locus includes all the known members of the 3A subfamily of the cytochrome P450 superfamily of genes.

CYP3A43 is the major subfamily protein expressed in the testis and prostate, whereas CYP3A7 is mainly expressed in fetal liver, placenta, and endometrium [25, 31 – 35]. CYP3A4 is the most studied isoform in the CYP3A subfamily and is predominant in the small intestine and adult liver.

Table 1 shows each CYP3A isoform in humans, mice, and rats. The expression levels and profiles, regulation, and function of CYP3A isoforms exhibit species-specific differences. ... View in...

CYP3A is one of the most important cytochrome P450 isoforms responsible for drug metabolism by humans because it is the major such enzyme in critical tissues such as the gastrointestinal tract and liver, and it is involved in the oxidative biotransformation of …

The CYP3A4 and CYP3A5 genes are located in a CYP3A gene locus on chromosome 7. The CYP3A4/5 genes are oriented on the negative strand of the chromosome, and therefore the coding DNA sequence is the reverse complement of the human reference genome sequence.

Cytochrome P450 (CYP) 3A4 is responsible for most CYP3A-mediated drug metabolism but the minor isoforms CYP3A5, CYP3A7 and CYP3A43 also contribute. CYP3A5 is the best studied of the minor CYP3A isoforms. It is well established that only approximately 20% of …

CYP3A is the most abundant, clinically significant group of cytochrome P-450 isoenzymes. The CYP3A group is composed of four major isoenzymes: CYP3A3, CYP3A4, CYP3A5, and CYP3A7. CYP3A4 is the most common and is implicated in the majority of drug interactions.

Mar 6, 2013 · The CYP3A subfamily, the most abundant subfamily of the CYP isoforms in the liver, consists of at least four isoforms: CYP3A4, 3A5, 3A7, and 3A43 [1, 2]. These four functional isoforms are located in tandem, and consist of a cluster spanning 231 kilobase pairs (kb) on chromosome 7 [1, 4].