Insulin receptor substrate 1 plays a key role in transmitting signals from the insulin receptor (IR) and insulin-like growth factor 1 receptor (IGF-1) to intracellular pathways PI3K / Akt and Erk MAP kinase pathways.

Mar 30, 2025 · IRS1 (Insulin Receptor Substrate 1) is a Protein Coding gene. Diseases associated with IRS1 include Type 2 Diabetes Mellitus and Three M Syndrome 1. Among its related pathways are IL-9 Signaling Pathways and Insulin receptor signalling cascade.

IRS1 promotes thyroid cancer metastasis through EMT and PI3K/AKT pathways. High risk genetic variants of human insulin receptor substrate 1 (IRS1) infer structural instability and functional interference.

Insulin receptor substrate 1 (IRS1) is a key mediator of insulin signal transduction. Perturbations involving IRS1 complexes may lead to the development of insulin resistance and type 2 diabetes (T2D).

Dec 1, 2003 · Insulin receptor substrate-1 (IRS1) is a substrate of the insulin receptor tyrosine kinase and appears to have a central role in the insulin-stimulated signal transduction pathway. Therefore, the IRS1 gene has been studied extensively as a candidate gene for type 2 diabetes.

Using in vivo (knockout) and in vitro (knockdown) studies targeting insulin receptor substrate (IRS) proteins, we compared the relative roles of IRS1 and IRS2 in regulating alpha cell function. Alpha cell–specific IRS1-knockout mice exhibited glucose intolerance and inappropriate glucagon suppression during glucose tolerance tests.

Mar 1, 2013 · IRS1 is an intracellular signaling adaptor protein that integrates and coordinates numerous biologically key extracellular signals within the cell. First identified as a signaling intermediate of the insulin receptor (IR), it is now clear that IRS1 is the main substrate of the insulin-like grow factor 1 receptor (IGF1R) (Dearth et al., 2007).

Aug 1, 2023 · Here, we found that the phase separation-mediated IRS-1 puncta attached to endoplasmic reticulum (ER). VAPB, an ER-anchored protein that mediates tethers between ER and membranes of...

Insulin receptor substrate-1 (IRS1) is a docking protein for both the insulin receptor (INSR; 147670) and the type 1 insulin-like growth factor receptor (IGF1R; 147370). It binds to and activates phosphatidylinositol 3-kinase (PI3K; see 171834) and plays an important role in signal transduction from these receptors.

Signal transduction by the insulin receptor and its downstream regulator, insulin receptor substrate 1 (IRS1), are key elements in the mechanism of glucose uptake in muscle and adipose tissue.