Aims: Novel therapies are needed for recurrent pericarditis, particularly when corticosteroid dependent and colchicine resistant. Based on limited data, interleukin-1 blockade with anakinra may be beneficial. The aim of this multicentre registry was to evaluate the broader effectiveness and safety of anakinra in a 'real world' population.

Feb 24, 2021 · In the international registry of Anakinra for Pericarditis (IRAP) study, the largest reported observational study of an IL-1 antagonist for the treatment of recurrent pericarditis, the primary endpoint of reduction of recurrence of pericarditis and secondary endpoints of reduction of hospitalization and corticosteroid dependence were met and ...

2022 Vehicle Speeds and the iRAP Protocols: A Review. iRAP is reviewing its speed risk factors used in the pedestrian and bicyclist Star Rating models to ensure they reflect the latest research and support Safe System outcomes. This review includes a literature review and discussions with leading experts in this field.

Apr 4, 2025 · A recently published impact evaluation overstates the benefits of IRAP protocols in reducing traffic injuries. This ICoRSI Position Statement clarifies the biases in the methods used in this study and how its findings should be interpreted.

Jun 3, 2020 · In the current study, we aim to investigate if the IRAP can be a suitable measure of hopelessness in elderly people. In particular, we are interested in investigating how IRAP scores correlate with BHS scores and how older people perform the IRAP tasks.

Jul 16, 2020 · To address this issue, the authors propose that an adaptation of the Implicit Relational Assessment Procedure (IRAP; Barnes-Holmes, Barnes-Holmes, Stewart, & Boles, 2010a) can be used to assess change agendas.

Thirty-seven participants (average age = 65) with normal cognitive functioning completed the Beck Hopelessness Scale (BHS) and an IRAP designed to measure hopelessness. Results revealed significant correlations between BHS and IRAP scores.

Objective: The Israel Registry for Alzheimer's Prevention (IRAP) is a prospective longitudinal study of asymptomatic middle-aged offspring of AD patients (family history positive; FH+) and controls (whose parents have aged without dementia; FH-) aimed to unravel the contribution of midlife factors to future cognitive decline and dementia. Here ...

Oct 1, 2022 · The current study explored the feasibility and potential utility of a natural-language IRAP for examining psychological inflexibility in primary school children. 44 children (age range: 10–11 years old) underwent two different IRAP tasks.

Nov 13, 2023 · In the current study, we demonstrate that small molecular weight IRAP inhibitors reduce infarct volume and improve neurological outcome in a hypertensive animal model of ischemic stroke.