Ionomycin is an ionophore and an antibiotic that binds calcium ions (Ca 2+) in a ratio 1:1. It is produced by the bacterium Streptomyces conglobatus. [3] . It binds also other divalent cations like magnesium and cadmium, but binds Ca 2+ preferably. [1][2] It has 14 chiral centers.

Ionomycin is a calcium ionophore that increases intracellular Ca++ levels, possibly relating to endonuclease activation of lymphocytes and decreased ratio of Bcl-2 to Bax and ultimately apoptosis. In addition, this agent is used to investigate …

Ionomycin is a polyether ionophore that chelates calcium (and cadmium) in the form of dibasic acids (35). From: Archives of Medical Research, 2001

Ionomycin is a membrane permeable calcium ionophore produced by the bacterium Streptomyces conglobatus. This ionophore facilitates the transfer of calcium ions (Ca2+) into and out of cells. Ionomycin can be used to increase intracellular calcium levels triggering cell death through apoptosis and aut

5 days ago · Ionomycin is a potent and selective calcium ionophore agent (1,2). The molecule acts as a motile Ca 2+ carrier and enhances Ca 2+ influx by direct stimulation of store-regulated cation entry across biological membranes (3). At the micromolar level, ionomycin can activate Ca 2+ /Calmodulin dependent kinase and phosphatase to stimulate gene ...

Jun 26, 2019 · Ionomycin is a calcium ionophore used to increase intracellular calcium concentration, it does so by: Facilitating the transport of Ca 2+ across the plasma membrane. Releasing Ca 2+ from its intracellular stores without the involvement of G proteins, resulting in the activation of calcium-activated chlorine channels.

Ionomycin is a potent and selective calcium ionophore derived from Streptomyces conglobatus (Liu et al.). It is used as a research tool to rapidly raise the intracellular level of calcium, and to study calcium transport across biological membranes by inducing the release of cytosolic calcium stores (Morgan & Jacob; Yoshida & Plant).

Jul 20, 2024 · The ability of ionomycin to precisely modulate calcium levels makes it a powerful agent for investigating calcium-dependent signaling pathways. The combined use of PMA and ionomycin creates a synergistic effect, amplifying the activation of T-cells.

Ionomycin is a membrane permeable calcium ionophore produced by the bacterium Streptomyces conglobatus. This ionophore facilitates the transfer of calcium ions (Ca2+) into and out of cells1. Ionomycin can be used to increase intracellular calcium levels triggering cell death through apoptosis and autophagy1. Ionomycin is commonly used in

Oct 3, 2018 · Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis.